Unilateral pallidotomy in Parkinson's disease: a randomised, single-blind, multicentre trial

Bie, Rob M.A. de; Haan, Rob J. de; Nijssen, Peter C.G.; Rutgers, A.W.F.; Beute, Guus; Bosch, Dirk; Haaxma, R.; Schmand, Ben; Schuurman, P. Richard; Staal, Michiel J.; Speelman, Johannes D.

doi:10.1016/s0140-6736(99)03556-4

Cited by 160 publications

(117 citation statements)

References 21 publications

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“…O dystonia is also improved. These results have been con®rmed in a randomized, single-blind, multicenter trial (De Bie et al, 1999). However, only a few studies have a follow up of more than 1 year (Laitinen et al, 1992;Fazzini et al, 1997;Lang et al, 1997;Kondziolka et al, 1999;Samii et al, 1999;Baron et al, 2000;Fine et al, 2000).…”

Section: Pallidotomymentioning

confidence: 86%

Mirthful laughter induced by subthalamic nucleus stimulation

et al. 2001

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Copper salts, which are abundant, relatively inexpensive and possess low toxicity, have long been used as versatile catalysts for various reactions in organic synthesis. Recently, the development of Cu‐catalyzed or ‐mediated CH functionalization reactions has gained significant attention. Since the pioneering work of Daugulis on the introduction of 8‐aminoquinoline and picolinic acid auxiliaries as removable directing groups in transition metal‐catalyzed CH bond activations, the combination of copper salts with these bidentate directing groups has emerged as an innovative strategy for the construction of carbon‐carbon or carbon‐heteroatom bonds through CH bond cleavage. In addition to the 8‐aminoquinoline and picolinamide systems, several other bidentate directing groups including the 2‐aminophenyloxazoline group by Yu and Dai and the PIP system by Shi, have been developed as well. This review intends to cover most of the recent advances on copper‐catalyzed or ‐mediated direct sp2 and sp3 CH bond functionalizations assisted by these bidentate directing groups. The major achievements in this area are discussed and catalogued by the type of bonds formed (CC, CO, CN, CS, CP etc.). Special attention is paid to the reaction mechanisms. Selected examples of substrates are listed as well. In addition, a personal outlook is given at the end.

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Section: Pallidotomymentioning

confidence: 86%

Mirthful laughter induced by subthalamic nucleus stimulation

et al. 2001

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“…Injection of adeno/lenti-associated virus that expresses wild-type or mutant a-syn into rat, mice or non-human primate SN produced loss of dopaminergic neurons, but the effect is not easily reproduced in transgenic mice overexpressing alpha-synuclein Rationale for the role of autophagy: Early dendritic and axonal dystrophy, reduction of striatal dopamine content, and the formation of somatic and dendritic ubiquitinated inclusions in DA neurons were prevented by ablation of Atg7 (an essential autophagy gene ) Rationale for the role of UPS/ALP: Protection from DA neuronal death was also observed in multiple experiments through the pharmacological modulation of the UPS, ALP system; however, there are also contradicting data in the literature Zhu et al, 2007; However, although many lines of evidence exist to support essentiality of impaired proteostasis, a single molecular chain of events cannot be established Clinical and experimental evidences show that the pharmacological replacement of the DA neurofunction by allografting fetal ventral mesencephalic tissues is successfully replacing degenerated DA neurons resulting in the total reversibility of motor deficit in animal model and partial effect is observed in human patient for PD Lopez-Lozano et al, 1991; Also, administration of L-DOPA or DA agonists results in an improvement of motor deficits . The success of these therapies in man as well as in experimental animal models clearly confirms the causal role of dopamine depletion for PD motor symptoms (Cotzias et al, 1969;Matsumoto et al, 1976;Narabayashi et al, 1984;Kelly et al, 1987;Lopez-Lozano et al, 1991;Uitti et al, 1996Uitti et al, , 1997Silva et al, 1997;Lang et al 1998;Scott et al, 1998;De Bie et al, 1999;Walter et al, 2004;...…”

Section: Essentialitymentioning

confidence: 72%

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

Ockleford¹,

Adriaanse²,

Berny³

et al. 2017

EFS2

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In 2013, EFSA published a literature review on epidemiological studies linking exposure to pesticides and human health outcome. As a follow up, the EFSA Panel on Plant Protection Products and their residues (PPR Panel) was requested to investigate the plausible involvement of pesticide exposure as a risk factor for Parkinson's disease (PD) and childhood leukaemia (CHL). A systematic literature review on PD and CHL and mode of actions for pesticides was published by EFSA in 2016 and used as background documentation. The Panel used the Adverse Outcome Pathway (AOP) conceptual framework to define the biological plausibility in relation to epidemiological studies by means of identification of specific symptoms of the diseases as AO. The AOP combines multiple information and provides knowledge of biological pathways, highlights species differences and similarities, identifies research needs and supports regulatory decisions. In this context, the AOP approach could help in organising the available experimental knowledge to assess biological plausibility by describing the link between a molecular initiating event (MIE) and the AO through a series of biologically plausible and essential key events (KEs). As the AOP is chemically agnostic, tool chemical compounds were selected to empirically support the response and temporal concordance of the key event relationships (KERs). Three qualitative and one putative AOP were developed by the Panel using the results obtained. The Panel supports the use of the AOP framework to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify data gaps, define a tailored testing strategy and suggests an AOP's informed Integrated Approach for Testing and Assessment (IATA).

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“…Several other studies have confirmed the significant and sustained anti-dyskinesia effect of pallidotomy (de Bie et al, 1999;Merello et al, 1999). The mechanism of action of pallidotomy in reducing drug-induced dyskinesias is more complex.…”

Section: Pathophysiology Of Drug-induced Dyskinesias 99mentioning

confidence: 91%