Unilateral permanent loss of vision after nefopam administration

Corbonnois, G.; Iohom, Gabriella; Lazarescu, C.; Hubert, I.; Bouaziz, Hervé

doi:10.1016/j.annfar.2013.04.015

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…Although nefopam is considered well tolerated in therapeutic dose ranges, uncommon and sometimes fatal adverse events have been reported with this drug. 31 , 32 For example, a case of postoperative permanent blindness 31 and several cases of fatal intoxication. 32 In addition, one study reported an unexpected increase in its plasma levels even though the doses were within the therapeutic range.…”

Section: Discussionmentioning

confidence: 99%

Opioid sparing effect and safety of nefopam in patient controlled analgesia after laparotomy: A randomized, double blind study

et al. 2016

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ObjectivesA double-blind randomised study to evaluate the opioid sparing effect and safety of nefopam when administered via intravenous patient controlled analgesia (PCA) with fentanyl.MethodsPatients planned for elective open laparotomy, were randomly assigned to receive into fentanyl 25 µg/ml (SF group) or nefopam 2.4 mg/ml plus fentanyl 25 µg/ml (NF group). Patients were assessed before surgery and for 24 h postoperatively.ResultsTotal PCA fentanyl consumption was significantly lower in the NF group (n = 35) than the SF group (n = 36). Pain scores were significantly lower and patients’ satisfaction with treatment significantly better in the NF group than the SF group. Dry mouth and dizziness were significantly more frequent in the NF group than the SF group. There were no other statistically significant between-group differences in the incidence of adverse events.ConclusionsIntravenous PCA using nefopam + fentanyl following laparotomy has an opioid sparing effect and is associated with a low incidence of some of the typical opioid related adverse events.Trial registryClinicaltrials.gov Registration No: NCT02596269

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Section: Discussionmentioning

confidence: 99%

Opioid sparing effect and safety of nefopam in patient controlled analgesia after laparotomy: A randomized, double blind study

et al. 2016

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“…Nausea was significantly more frequent in the fentanyl group compared with nefopam groups. If available, nefopam could be used to reduce the opioid consumption and opioid-associated side effects, such as nausea, after an evaluation of the risk-to-benefit ratio of all available analgesic options and patient reassessment for potential side effects (tachycardia, glaucoma, seizure, and delirium) (89)(90)(91)(92).…”

Section: Nefopammentioning

confidence: 99%

Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Devlin

Skrobik

Gélinas

et al. 2018

Critical Care Medicine

2,591

2,938

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We found substantial agreement among a large, interdisciplinary cohort of international experts regarding evidence supporting recommendations, and the remaining literature gaps in the assessment, prevention, and treatment of Pain, Agitation/sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption) in critically ill adults. Highlighting this evidence and the research needs will improve Pain, Agitation/sedation, Delirium, Immobility (mobilization/rehabilitation), and Sleep (disruption) management and provide the foundation for improved outcomes and science in this vulnerable population.

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“…Il existe, au final, peu de contre-indications à l'utilisation du néfopam ; la principale reste l'existence d'un glaucome aigu ou chronique avec une tension oculaire mal contrôlée. Des cas de cécité ont été rapportés [15]. En cas d'insuffisance rénale terminale (clairance de la créatinine < 20 mL/ min), les posologies doivent être réduites de 50 % [16].…”

Section: Néfopamunclassified

Comment utiliser les antalgiques non opiacés en postopératoire ?

Beloeil

2015

La Presse Médicale

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Unilateral permanent loss of vision after nefopam administration

Cited by 6 publications

References 15 publications

Opioid sparing effect and safety of nefopam in patient controlled analgesia after laparotomy: A randomized, double blind study

Opioid sparing effect and safety of nefopam in patient controlled analgesia after laparotomy: A randomized, double blind study

Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Comment utiliser les antalgiques non opiacés en postopératoire ?

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