Unilateral persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous in a rabbit

Abstract

A 3-month wild rabbit was presented for examination of ocular opacities in the left eye. A complete bilateral ocular examination including slit-lamp examination, indirect ophthalmoscopy, tonometry, and ultrasound biomicroscopy was performed. Biomicroscopy of the lens of the left eye showed a retrolental fibrovascular membrane causing leukocoria. The opacity prevented biomicroscopy of the vitreous and funduscopy OS. No other disorder was present in either eye. Ultrasound examination did not show any difference between the right and left eye. Histopathological examination showed a 50-μm thick, preretinal, retrolental, nonpigmented, fibrovascular tissue. Posterior synechiae were present, but no other lesion of the posterior segment was found in this eye. These ocular abnormalities are consistent with a persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous (PHTVL/PHPV), similar to those described in other species.

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

“…Further maturation of the retina continues post eyelid opening for several weeks more or even to adulthood 215 , 216 , 335 , 336 . Regression of ocular fetal vessels (hyaloid vessels and vasculosa lentis) has been reported to be complete by about post-natal days 14–20 337 , 338 , but persistence of embryonic vessel remnants is common in rabbits 339 , 340 , 341 .…”

Persistent papillary membrane in Wistar laboratory rats ( Rattus Norvegicus, Albinus Variation, Wistar )

“…PPMs have been reported in different species of animals used for experimentation (YOUNG et al, 1974;TARADACH & GREAVES, 1984;BOILLOT et al, 2015). Among laboratory animals, PPM has been reported to occur in rats (YOUNG et al, 1974), mice, hamsters, Beagle dogs (TARADACH & GREAVES, 1984), and rabbits (BOILLOT et al, 2015). This condition has also been reported in several dog breeds including Basenji (ROBERTS & BISTNER, 1968;MITCHELL, 2011), Poodle (ARNBJERG, 1980, Doberman Pinscher (BARTOE et al, 2007), English Cocker Spaniel (STRANDE et al, 1988;MITCHELL, 2011) (ROPSTAD et al, 2007).…”

“…In the present study, since the affected rats all belonged to the same colony, it is possible that heredity was the probable cause of PPM. PPMs have been reported in different species of animals used for experimentation (YOUNG et al, 1974;TARADACH & GREAVES, 1984;BOILLOT et al, 2015). Among laboratory animals, PPM has been reported to occur in rats (YOUNG et al, 1974), mice, hamsters, Beagle dogs (TARADACH & GREAVES, 1984), and rabbits (BOILLOT et al, 2015).…”

Persistent Tunica Vasculosa Lentis in Full-Term Infants: A Report of Two Cases

“…They only differed in family history, where the second case had a mother with type 1 diabetes. Only a few human neonate cases of persistent TVL in full-term babies are reported in the literature, many in animals [6][7]. The natural course of TVL is to disappear completely between 13 and 16 weeks of gestation [3].…”