Unilateral Pleomorphic Lipoma of the Eyebrow

Abstract

Aim: Epithelial and soft tissue tumours of the eyebrow skin and subcutis are rare occurrences. We describe an unusual eyebrow subcutis mass in a 65-year-old female. Methods: A 65-year-old female presented with an 8- to 9-month history of a painless swelling over the right eyebrow that was sausage-shaped. The clinical differential diagnosis included neurofibroma/schwannoma, cyst, prolapsed fat or metastasis. The lesion was excised. Results: The histology revealed a lesion composed of rope-like collagen, some spindle cells, mature adipocytes and hyperchromatic multi-nucleate floret cells. The spindle and multi-nucleate floret cells showed immunohistochemical positivity for CD34. The features were of a primary pleomorphic lipoma. Conclusions: This is the first reported case of a pleomorphic lipoma of the eyebrow subcutis. We discuss the clinical and histological differential diagnosis, especially related to histological conditions with which pleomorphic lipoma can be confused, such as well-differentiated liposarcoma.

Pleomorphic Adenoma of the Eyebrow: An Unexpected Finding and Review of Unusual Periorbital Soft Tissue Lesions

“…The most common benign soft tissue lesions of the eyebrow include dermoid cysts, inclusion cysts, sebaceous cysts, pilomatrixoma, and basal cell carcinoma 1 . Among these lesions, the most common in the adult population are dermoid cysts, and the most common in children are pilomatrixomas followed by dermoid cysts 15 . In the pediatric population, the most common midline craniofacial lesions include dermoid cysts, gliomas, and encephaloceles.…”

“…1 Among these lesions, the most common in the adult population are dermoid cysts, and the most common in children are pilomatrixomas followed by dermoid cysts. 15 In the pediatric population, the most common midline craniofacial lesions include dermoid cysts, gliomas, and encephaloceles. Nasal dermoids are rare (5%-10% of all dermoid cysts), and a specific subtype called nasal dermoid sinus cyst has the potential for development of intracranial connection.…”