Unilateral Temporal Lobe Damage and the Partial Kluver–Bucy Syndrome

Bates, Gordon; Sturman, S. G.

doi:10.1155/1995/293905

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…In an early study, Downer (1961) demonstrated that unilateral amygdala lesions in a split-brain monkey were capable of producing a Kliiver-Bucy syndrome but only in reaction to visual stimuli when visual input was restricted to the hemisphere ipsilateral to the lesion. More recently, rare cases of full (Ghika-Schmid, Assal, DeTribolet, & Regli, 1995) and partial (Bates & Sturman, 1995) Kltiver-Bucy syndrome in humans with unilateral temporal lobe damage have been reported.…”

Section: Values Represent Group Means (+ Sem) Amentioning

confidence: 99%

Partial disruption of fear conditioning in rats with unilateral amygdala damage: Correspondence with unilateral temporal lobectomy in humans.

LaBar¹,

LeDoux²

1996

Behavioral Neuroscience

104

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Conditioned fear in rats was assessed for the effects of pretraining amygdala lesions (unilateral vs. bilateral) across unconditioned stimulus (US) modalities (white noise vs. shock). In contrast to sham controls, unilateral amygdala lesions significantly reduced conditioned freezing responses, whereas bilateral amygdala lesions resulted in a nearly complete lack of freezing to both the conditioned stimulus (CS) and the context. The lesion effects were more pronounced for CS conditioning but were consistent across US modalities. It was concluded that white noise can serve as an effective US and that unilateral amygdala lesions attenuate but do not eliminate conditioned fear in rats. The results support our interpretation of a recent fear conditioning study in humans (K. S. LaBar, J. E. LeDoux, D. D. Spencer, & E. A. Phelps, 1995).In a recent study, we demonstrated impaired fear conditioning in human patients with unilateral temporal lobe resection to control medically refractory epilepsy (LaBar, LeDoux, Spencer, & Phelps, 1995). These patients were deficient in producing conditioned responses (CRs) on paired conditioned stimulus (CS)-unconditioned stimulus (US) acquisition trials. This result was consistent across both simple and conditional discrimination tasks and could not be attributed to deficits in declarative memory or sensorimotor function. On the basis of animal models of conditioned fear (for reviews, see Davis, 1992Davis, , 1994Fanselow, 1994;Kapp, Wilson, Pascoe, Supple, & Whalen, 1990;LeDoux, 1990LeDoux, , 1995aLeDoux, , 1995b, we suggested that the impairment may be related to the patients' sustained damage to the amygdala, although the epileptiform activity and subsequent surgical excision encompassed other structures in the medial temporal lobe.In contrast to typical animal models, however, the LaBar et al. (1995) study differed in several ways, including that (a) a loud white noise burst was used as the US, and (b) the extent of amygdala damage was predominantly unilateral. As a consequence, we did not have direct support for our interpretation of the human study when extrapolating from the existing animal literature. Most neurobiological work in this area has relied on the use of footshock as a US, despite the fact that the afferent neural pathways signaling footshock elicitation are not well-understood (Davis, 1992). An early study by Lyon (1964) used a loud noise US to examine the role of midbrain structures in avoidance conditioning, and more recently, white noise has been shown to serve as an effective unconditioned Kevin S. LaBar and Joseph E. LeDoux, Center for Neural Science, New York University.We wish to thank Keith Corodimas and Kate Melia for their assistance. This study was supported in part by U.S. Public Health Service Grants MH00956, MH10537, and MH38774.Correspondence concerning this article should be addressed to Joseph E. LeDoux, Center for Neural Science, New York University, 4 Washington Place, Room 809, New York, New York 10003. Electronic mail may be sent via Internet to ...

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Section: Values Represent Group Means (+ Sem) Amentioning

confidence: 99%

Partial disruption of fear conditioning in rats with unilateral amygdala damage: Correspondence with unilateral temporal lobectomy in humans.

LaBar¹,

LeDoux²

1996

Behavioral Neuroscience

104

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“…The selective decline in the PIQ, the mild episodic visual memory deficits, difficulties on visuomotor tracking tasks, and aprosody could be considered as posttraumatic neuropsychological sequels, and could be explained with predominant posttraumatic right hemispheric lesion [5,9]. Organic hyperphagia is an uncommon condition that occurs in KLS, Kluver-Bucy syndrome, Prader-Willi syndrome, hypothalamic and, occasionally, in thalamic lesions [1]. The human Kluver-Bucy syndrome has been divided into six component symptoms: visual agnosia, placidity, altered sexual behavior, hyperorality, altered dietary habits (the only symptom from this group undoubtedly present in our patient) and hypermetamorphosis, and a minimum of three of these symptoms was required for the diagnosis of the partial form of this syndrome [13].…”

Section: Discussionmentioning

confidence: 99%

“…Even in the partial syndrome, the characteristic behavior cluster of the Kluver-Bucy syndrome was thought to be diagnostic of bilateral temporal damage. However, Bates and Sturman [1] reported a woman with hyperphagia, placidity and hyposexuality associated with gross atrophy of her right temporal lobe following neurosurgery.…”

Section: Discussionmentioning

confidence: 99%

A Variant of the Kleine‐Levin Syndrome following Head Trauma

Kostić¹,

Stefanova²,

Svetel³

et al. 1998

Behavioural Neurology

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A 19-year-old man developed the Kleine-Levin syndrome three weeks after the head trauma and subsequent neurosurgical evacuation of right-sided, fronto-temporal epidural hematoma. The expression of periodic episodes was observed for hypersomnolence and, to a lesser degree, for behavioral disturbances, while the hyperphagia was constantly present during a period of 1.5 years. These clinical features were associated with the focal, right-sided hypothalamic lesion and ipsilateral posttraumatic parenchymal temporal lobe damage on NMR imaging.

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“…37 Dietary restriction and practical approaches like the use of refrigerator locks are the most obvious interventions but not always possible. The resulting weight gain causes additional morbidity and even mortality.…”

Section: Feeding Disordersmentioning

confidence: 99%

“…The resulting weight gain causes additional morbidity and even mortality. 37 Dietary restriction and practical approaches like the use of refrigerator locks are the most obvious interventions but not always possible. There is only a case report literature to guide the clinician in this challenging area.…”

Section: Feeding Disordersmentioning

confidence: 99%

Medication in the treatment of the behavioural sequelae of traumatic brain injury

Bates

2006

Dev Med Child Neurol

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A significant proportion of children who sustain traumatic brain injury will go on to experience disturbance in their academic, emotional, and social functioning. There is a role for medication in the treatment of these late onset changes. This review will focus on the recognition and pharmacological treatment of the most common and most problematic presentations that may follow head injury, and supports the use of stimulant medication for secondary attention-deficit-hyperactivity disorder despite the small evidence base for use in children.

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Unilateral Temporal Lobe Damage and the Partial Kluver–Bucy Syndrome

Cited by 5 publications

References 6 publications

Partial disruption of fear conditioning in rats with unilateral amygdala damage: Correspondence with unilateral temporal lobectomy in humans.

Partial disruption of fear conditioning in rats with unilateral amygdala damage: Correspondence with unilateral temporal lobectomy in humans.

A Variant of the Kleine‐Levin Syndrome following Head Trauma

Medication in the treatment of the behavioural sequelae of traumatic brain injury

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