Unilateral tonsil enlargement in children and adults: is routine histology tonsillectomy warranted? A multi-centre series of 323 patients

Abstract

Background. This study aimed to establish whether histology tonsillectomy is justified for unilateral tonsil enlargement. Methods. A retrospective review was conducted of histology tonsillectomies in three health organisations over five years, with strict exclusion criteria, focusing on benign-appearing unilateral tonsil enlargement. Results. Ninety paediatric and 233 adult cases were included. No paediatric cases and five adult cases of malignancy were detected. All malignant cases presented with other symptoms. Using binary logistic regression, a history of rapid unilateral tonsil enlargement was the only factor found to be significantly associated with malignant outcome. Thirty-three per cent of subjectively larger tonsils were smaller on post-operative histological measurement. Of the cases, 12.1 per cent re-presented with post-tonsillectomy bleeding. Conclusion. The authors recommend avoiding histology tonsillectomy for unilateral tonsil enlargement unless 'red flag' signs of malignancy are present, with particular attention to rapid unilateral tonsil enlargement. This study demonstrated discrepancy between clinical examination findings and true tonsil asymmetry; there may be a role for cross-sectional imaging prior to histology tonsillectomy in high-risk patients.

Vitamin D and smell impairment, routine histology for unilateral tonsillar enlargement, and a machine learning model for predicting the three-year survival status of patients with hypopharyngeal squamous cell carcinoma

“…A study by Edwards et al in this month's issue of The Journal addresses the question of whether tonsillectomy for histopathology is justified for cases of unilateral tonsil enlargement. 5 The study included 323 patients (90 paediatric and 233 adult cases) involving three health organisations over five years, with strict exclusion criteria, focusing on benign-appearing unilateral tonsil enlargement.…”