2022
DOI: 10.1038/s41598-021-04086-x
|View full text |Cite
|
Sign up to set email alerts
|

Unilateral zebrafish corneal injury induces bilateral cell plasticity supporting wound closure

Abstract: The cornea, transparent and outermost structure of camera-type eyes, is prone to environmental challenges, but has remarkable wound healing capabilities which enables to preserve vision. The manner in which cell plasticity impacts wound healing remains to be determined. In this study, we report rapid wound closure after zebrafish corneal epithelium abrasion. Furthermore, by investigating the cellular and molecular events taking place during corneal epithelial closure, we show the induction of a bilateral respo… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
11
0

Year Published

2022
2022
2023
2023

Publication Types

Select...
4
2

Relationship

2
4

Authors

Journals

citations
Cited by 7 publications
(13 citation statements)
references
References 57 publications
2
11
0
Order By: Relevance
“…10). We confirmed the results obtained previously (Ikkala et al, 2022), namely the loss of Pax6a expression in central cornea during the wound healing period. The krtt1c19e expression exhibited an interesting dynamics.…”
Section: Resultssupporting
confidence: 92%
See 2 more Smart Citations
“…10). We confirmed the results obtained previously (Ikkala et al, 2022), namely the loss of Pax6a expression in central cornea during the wound healing period. The krtt1c19e expression exhibited an interesting dynamics.…”
Section: Resultssupporting
confidence: 92%
“…The loss of one pax6 allele, such as seen in the context of the rare disease called aniridia, as well as Pax6 overexpression showed overlapping effects, such as reduced krt12 expression, reduced adult corneal diameter or thickness, and altered wound healing (Ramaesh et al, 2003;Dora et al, 2008). Thus, an appropriate level of Pax6 is necessary to maintain corneal integrity, as we presented previously (Ikkala et al, 2022).…”
Section: Introductionmentioning
confidence: 59%
See 1 more Smart Citation
“…The loss of one Pax6 allele, such as seen in the context of the rare disease called aniridia, characterized by an hypoplasia or lack of iris, as well as Pax6 overexpression, showed overlapping effects such as reduced krt12 expression, reduced adult corneal diameter or thickness, and altered wound healing (Ramaesh et al, 2003;Dora et al, 2008). Thus, an appropriate level of Pax6 is necessary to maintain corneal integrity, as we have previously demonstrated in zebrafish cornea (Ikkala et al, 2022b).…”
Section: Introductionmentioning
confidence: 79%
“…Pax6a expression was suppressed during the wound healing process (Ikkala et al, 2022b). Therefore, here we followed the expression of these two markers during wound healing to investigate a possible reset of corneal maturation during that process.…”
Section: Modulation Of Corneal Epithelial Markers During Wound Healingmentioning
confidence: 99%