Unipolar Brush Cells of the Cerebellum Are Produced in the Rhombic Lip and Migrate through Developing White Matter

Englund, Chris; Kowalczyk, Tom; Daza, Ray A. M.; Dagan, Avner; Lau, Charmaine; Rose, Matthew F.; Hevner, Robert F.

doi:10.1523/jneurosci.1610-06.2006

Cited by 223 publications

(265 citation statements)

References 42 publications

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“…While the data shown do not really allow these cells to be identiWed, their distribution is highly suggestive of unipolar brush cells, and clearly raises the issue as to the existence of an independent lineage as early as E10.5 in the mouse. This interpretation would also be consistent with the conclusion reached by Englund et al (2006) that UBCs originate from the rhombic lip, as wnt-1 expression within the cerebellar anlage is restricted to this structure at E 10.5 (i.e. at the time the putative UBCs described by Zervas et al were genetically marked; Li et al 2002).…”

Section: Unipolar Brush Cellssupporting

confidence: 87%

“…The recent observation that UBCs and their precursors express the transcription factor Tbr2 allowed for the Wrst time to locate and follow these cells in the cerebellar anlage (Englund et al 2006). These studies showed that precursors of UBCs can be localized to the rhombic lip in the early (E 13.5 in the mouse) cerebellar anlage, from where they translocate into the cerebellar granule cell layer (cortex) via the nascent cerebellar white matter.…”

Section: Unipolar Brush Cellsmentioning

confidence: 99%

“…While the work of Englund et al (2006) clearly documents that the numerical expansion of the Tbr2-positive population is critically dependent on Math1 expression, it is less obvious whether this reXects a cell-intrinsic dependency, or rather an early regulatory interaction between the Math1-positive granule cell lineage and that of UBCs. Thus, while the authors report weak expression of ß-galactosidase from the Math1 locus in Tbr2 positive cells, it remains open whether this is indeed indicative of expression of cognate Math1 in these cells, which would also be suggestive of a molecular relationship between these lineages.…”

Section: Unipolar Brush Cellsmentioning

confidence: 99%

“…While UBC positioning is disturbed in reeler mice (Ilijic et al 2005), it is not decided whether this is a direct eVect or rather a reXection of the general disorganization of the cerebellar cortex in these mutants (Ilijic et al 2005;Englund et al 2006).…”

Section: Unipolar Brush Cellsmentioning

confidence: 99%

See 3 more Smart Citations

Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex

Schilling

Oberdick

Rossi

et al. 2008

Histochem Cell Biol

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Ever since the groundbreaking work of Ramon y Cajal, the cerebellar cortex has been recognized as one of the most regularly structured and wired parts of the brain formed by a rather limited set of distinct cells. Its rather protracted course of development, which persists well into postnatal life, the availability of multiple natural mutants, and, more recently, the availability of distinct molecular genetic tools to identify and manipulate discrete cell types have suggested the cerebellar cortex as an excellent model to understand the formation and working of the central nervous system. However, the formulation of a unifying model of cerebellar function has so far proven to be a most cantankerous problem, not least because our understanding of the internal cerebellar cortical circuitry is clearly spotty. Recent research has highlighted the fact that cerebellar cortical interneurons are a quite more diverse and heterogeneous class of cells than generally appreciated, and have provided novel insights into the mechanisms that underpin the development and histogenetic integration of these cells. Here, we provide a short overview of cerebellar cortical interneuron diversity, and we summarize some recent results that are hoped to provide a primer on current understanding of cerebellar biology.

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Section: Unipolar Brush Cellssupporting

confidence: 87%

Section: Unipolar Brush Cellsmentioning

confidence: 99%

Section: Unipolar Brush Cellsmentioning

confidence: 99%

Section: Unipolar Brush Cellsmentioning

confidence: 99%

See 2 more Smart Citations

Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex

Schilling

Oberdick

Rossi

et al. 2008

Histochem Cell Biol

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show abstract

“…Surprisingly, the Math1+ RL gives rise not only to glutamatergic granule neurons, but to all known glutamatergic neurons of the cerebellum. These include both unipolar brush cells, which serve as a relay cell amplifying the excitatory effects of mossy afferent fibers on granule cells [12], as well as the glutamateric subset of deep cerebellar nuclei neurons, [13][14][15][16][17][18] (Figure 1A). Thus, the well ordered cellular organization of the mature cerebellum is achieved through the bipartite origins of its constituent neurons.…”

Section: Distinct Origins For Gabaergic and Glutamatergic Cerebellar mentioning

confidence: 99%

Cerebellar development and disease

Millen¹,

Gleeson²

2008

Current Opinion in Neurobiology

171

141

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The molecular control of cell type specification within the developing cerebellum as well as the genetic causes of the most common human developmental cerebellar disorders have long remained mysterious. Recent genetic lineage and loss-of-function data from mice have revealed unique and non-overlapping anatomical origins for GABAergic neurons from ventricular zone precursors and glutamatergic cell from rhombic lip precursors, mirroring distinct origins for these neurotransmitterspecific cell types in the cerebral cortex. Mouse studies elucidating the role of Ptf1a as a cerebellar ventricular zone GABerigic fate switch were actually preceded by the recognition that PTF1A mutations in humans cause cerebellar agenesis, a birth defect of the human cerebellum. Indeed, several genes for congenital human cerebellar malformations have recently been identified, including genes causing Joubert syndrome, Dandy-Walker malformation and Ponto-cerebellar hypoplasia. These studies have pointed to surprisingly complex roles for transcriptional regulation, mitochondrial function and neuronal cilia in patterning, homeostasis and cell proliferation during cerebellar development. Together mouse and human studies are synergistically advancing our understanding of the developmental mechanisms that generate the uniquely complex mature cerebellum.

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The derivatives of the Wnt3a lineage in the central nervous system

Louvi

Yoshida

Grove

2007

J of Comparative Neurology

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The dorsal midline of the vertebrate neural tube is a source of signals that direct cell fate specification and proliferation. Using genetic fate mapping in the mouse and a previously generated Wnt3aCre line, we report here that genetically labeled cells of the Wnt3a lineage migrate widely from the dorsal midline into the dorsal half of the adult brain and spinal cord, contributing to diverse structures in the diencephalon, midbrain, and brainstem and extensively populating the rostral spinal cord. Conspicuously, many of these structures are linked in specific functional networks. Wnt3a lineage cells populate nuclei of the central auditory system from the medulla to thalamus, and the trigeminal sensory system from the cervical spinal cord to the midbrain. Our findings reveal the rich contributions of the Wnt3a lineage to a variety of brain structures and show that functionally integrated nuclei can share a molecular identity, provided by transient gene expression early in their development.

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Unipolar Brush Cells of the Cerebellum Are Produced in the Rhombic Lip and Migrate through Developing White Matter

Cited by 223 publications

References 42 publications

Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex

Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex

Cerebellar development and disease

The derivatives of the Wnt3a lineage in the central nervous system

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