Unique and Varied Contributions of Traditional CVD Risk Factors: A Systematic Literature Review of CAD Risk Factors in China

Foody, JoAnne M.; Huo, Yong; Ji, Linong; Zhao, Dong; Boyd, Dylan; Meng, Hui; Shiff, Susan; Hu, Dayi

doi:10.4137/cmc.s10225

Cited by 22 publications

(15 citation statements)

References 31 publications

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“…The multivariate logistic regression analysis showed that smoking was also positively correlated with CAD, and was one of the risk factors of CAD (correlation coefficient =7.036, P<0.001). Epidemiological investigation and clinical studies worldwide have also confirmed that smoking is an independent risk factor of CAD ( 11 , 17 , 18 ). The risk of CAD for smokers is 1.5- to 4-fold that of non-smokers.…”

Section: Discussionmentioning

confidence: 85%

Correlation between coronary artery disease and obstructive sleep apnea syndrome and analysis of risk factors

et al. 2018

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The correlation between coronary artery disease (CAD) and obstructive sleep apnea syndrome (OSAS) was investigated to analyze its risk factors. A total of 84 patients with suspected CAD due to chest tightness and pain or nocturnal angina, were selected. They were admitted and received coronary angiography in The Affiliated Hospital of Medical College Qingdao University from March, 2016 to June, 2017. The vital signs were monitored, and the sleep monitoring was performed before and after coronary angiography. Before angiography, the fasting blood was drawn for blood biochemical detection, followed by routine electrocardiogram and echocardiographic examination. In addition, the body mass index was calculated and whether patients suffered from hypertension and diabetes mellitus was observed. The patients were divided into the control group (patients with a negative coronary angiography) and the CAD group (patients with a positive coronary angiography). There were 34 cases in the control group, including 21 cases of OSAS (61.76%), and 50 in the CAD group, including 40 cases of OSAS (80.00%). Statistical analysis revealed that there were statistically significant differences in the apnea hypopnea index (AHI), lowest oxygen saturation, degree of coronary stenosis (Gensini score) and triglyceride level between the two groups (P<0.05). There were no statistically significant differences in the cholesterol level and prevalence rates of hypertension and diabetes mellitus between the two groups. Logistic regression analysis revealed that smoking and AHI >20 were the risk factors of CAD (OR=7.036 and 5.377). Thus, CAD is closely correlated with OSAS and AHI >20 is one of the risk factors of CAD.

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Section: Discussionmentioning

confidence: 85%

Correlation between coronary artery disease and obstructive sleep apnea syndrome and analysis of risk factors

et al. 2018

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“…There were no significant differences in the levels of TC, TG, HDL-C, LDL-C and ApoAI between the two ethnic groups ( P > 0.05 for all). In contrast with developed countries, China has experienced a considerable increase in the prevalence of CAD over the past several decades [ 23 ]. Evidence of the relationship between dyslipidemia and CAD has been established worldwide.…”

Section: Discussionmentioning

confidence: 99%

Association of the ST3GAL4 rs11220462 polymorphism and serum lipid levels in the Mulao and Han populations

et al. 2014

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BackgroundA previous genome-wide association study has displayed the association of the ST3 beta-galactoside alpha-2,3-sialytransferase 4 (ST3GAL4) gene variant and lipid traits in the individuals of European ancestry, but the reproducibility of this association has not been detected in the Chinese population. The present study was undertaken to detect the association of ST3GAL4 rs11220462 single nucleotide polymorphism (SNP) and several environmental factors with serum lipid profiles in the Mulao and Han populations.MethodsA total of 700 unrelated individuals of Mulao nationality and 694 subjects of Han nationality were randomly selected from our previous stratified randomized samples. Genotypes of the SNP were determined via polymerase chain reaction and restriction fragment length polymorphism in combination with gel electrophoresis, and then verified by direct sequencing.ResultsSerum apolipoprotein (Apo) B levels were higher and the ApoAI/ApoB ratio was lower in Mulao than in Han (P < 0.05-0.01). There were no significant differences in the genotypic and allelic frequencies of the ST3GAL4 rs11220462 SNP between the two ethnic groups or between males and females. The A allele carriers in both Mulao males and females had higher total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and ApoB levels than the A allele non-carriers (P < 0.05-0.01). The subjects with AA genotype in Han males but not in females had higher TC and triglyceride (TG) levels than the subjects with AG or GG genotype (P < 0.01 for each). Multiple linear regression analyses showed that the levels of TC, LDL-C and ApoB in Mulao females; TC and LDL-C in Mulao males; and TC in Han males were correlated with the genotypes (P < 0.05-0.001). Serum lipid parameters were also associated with several environmental factors in both ethnic groups (P < 0.05 -0.001).ConclusionsThe association of ST3GAL4 rs11220462 SNP and serum lipid levels was different between the Mulao and Han populations, suggesting that there may be a racial/ethnic-specific association, and/or sex-specific association between the ST3GAL4 rs11220462 SNP and serum lipid parameters in some ethnic groups.

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“…The incidence of CAD in developing countries has increased quickly in recent years due to an increasing exposure to CAD risk factors, including diabetes, hypercholesterolemia, hypertension and smoking (3,4). CAD causes >2 million fatalities each year in China (5), resulting in extensive health problems and a burden to society.…”

Section: Introductionmentioning

confidence: 99%

Association between LGALS2 3279C>T and coronary artery disease: A case-control study and a meta-analysis

et al. 2014

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Coronary artery disease (CAD) has become the main cause of mortality worldwide. Lectin galactoside-binding soluble-2 () is involved in the cytokine lymphotoxin-α (LTA) cascade that may influence the progress of CAD. The aim of the present study was to assess the association between the 3279C>T (rs7291467) polymorphism and CAD. A total of 562 cases and 572 controls were recruited to examine the association. A systematic meta-analysis was performed to evaluate the contribution of 3279C>T polymorphism to the risk of CAD among 12,093 cases and 11,020 controls. There was no significant association found in the present case-control study. However, the meta-analysis showed that 3279C>T played a protective role in CAD [P=0.008, odds ratio (OR), 0.90; 95% confidence interval (95% CI), 0.82-0.97] and particularly in the Asian population (P=0.006; OR, 0.82; 95% CI, 0.71-0.94). The present case-control study did not find a significant association between 3279C>T and CAD in the Eastern Han Chinese population. However, the meta-analysis indicated that 3279C>T played a protective role in CAD, suggesting an ethnic difference in the association of the locus with CAD.

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Unique and Varied Contributions of Traditional CVD Risk Factors: A Systematic Literature Review of CAD Risk Factors in China

Cited by 22 publications

References 31 publications

Correlation between coronary artery disease and obstructive sleep apnea syndrome and analysis of risk factors

Correlation between coronary artery disease and obstructive sleep apnea syndrome and analysis of risk factors

Association of the ST3GAL4 rs11220462 polymorphism and serum lipid levels in the Mulao and Han populations

Association between LGALS2 3279C>T and coronary artery disease: A case-control study and a meta-analysis

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