Unique catanionic vesicles as a potential “Nano-Taxi” for drug delivery systems. In vitro and in vivo biocompatibility evaluation

Stagnoli, Soledad; Luna, María Eugenia; Villa, Cristian C.; Alustiza, Fabrisio; Niebylski, A.; Moyano, Fernando; Correa, N. Mariano; Falcone, R. Darío

doi:10.1039/c6ra27020d

Cited by 25 publications

(18 citation statements)

References 51 publications

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“…Taking into account our previous characterization of BHD-AOT vesicles and, to use them as drug delivery agents, they were evaluated under different pH conditions. [64] The diameter values of the BHD-AOT vesicles determined by DLS at different times at low pHs values (pH ≤ 2) to simulate stomach like conditions show that the vesicles are stable during about 90 minutes, after that, the size value decreases sharply to almost half of the original size. Moreover, during the first 90 minutes of exposition, the polydispersity reminds almost constant and then increases abruptly.…”

Section: Introductionmentioning

confidence: 98%

Amphiphilic ionic liquids as sustainable components to formulate promising vesicles to be used in nanomedicine

Falcone

Correa

Silber

2020

Current Opinion in Green and Sustainable Chemistry

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Section: Introductionmentioning

confidence: 98%

Amphiphilic ionic liquids as sustainable components to formulate promising vesicles to be used in nanomedicine

Falcone

Correa

Silber

2020

Current Opinion in Green and Sustainable Chemistry

Self Cite

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“…In the case of mixture of cationic and anionic surfactant (catanionic mixture [CAM]), electrostatic interactions between head groups decrease the free energy; as a result, catanionic vesicles are formed 3 . Vesicles are microscopic spherical bilayer structure similar to plasma membrane 4 . The head group region is predominantly solvated, and polarity gradually decreases from hydrophilic head to bilayer center that is hydrophobic.…”

Section: Introductionmentioning

confidence: 99%

Effect of methanol on surfactants and surfactant–PEO mixtures

Bibi

Shah

Bibi

et al. 2021

Asia-Pacific J Chem Eng

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Methanol–water system possesses unusual interactions, which may affect surfactant self‐assembly. The main objective of this study was to investigate the interactions and aggregation behavior of ionic surfactants sodium dodecyl sulfate (SDS) and cetyltrimethylammonium bromide (CTAB) and their equimolar catanionic binary mixtures (CAM) and their ternary mixtures with poly(ethylene oxide) (PEO) in aqueous solutions containing different volume percentages of methanol. Conductometry, surface tensiometry, and dynamic light scattering were employed for this purpose. The aggregation in all the systems showed methanol‐dependent patterns. The maximum shifts observed in the critical aggregation concentrations were 5.5, 2.7, 6.3, 4.1, and 4.4 mM, respectively, for SDS, CTAB, CAM, SDS/PEO, and CTAB/PEO systems for variation in MeOH from 5% to 30% v/v. The change in dielectric of the media and chaotropic nature of methanol was responsible for alteration in self‐assembly. The nature of surfactant especially and head group hydrophobicity also played a significant role in the process. The maximum change in area per molecule (i.e., ~4 nm2) occurred for CTAB/PEO system. The aggregation was delayed in surfactant solutions; however, the presence of polymer induced aggregation due to favorable polymer–surfactant interactions involving the surfactant adsorption onto polymer chains and formation of mixed aggregates. The hydrodynamic radii for CTAB/PEO systems, which were nearly 10 times greater than those recorded for SDS/PEO, showed the transition of system to nonspherical aggregated states. In short, the presence of methanol retarded the aggregation in surfactant and surfactant–polymer systems.

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“…18,19 Recently, the potential of catanionic system has been evaluated for drug-delivery and related applications. 8,15,20 However, their candidature for sustained release of fertilizers has never been explored. Keeping in view the benefits associated with the use of catanionic mixture as a delivery system, the present work intends to investigate the potential of pseudo-zwitterionic system based on equimolar sodium dodecyl sulfate and hexadecyltrimethylammonium bromide (HTAB) for sustained-urea release.…”

Section: Introductionmentioning

confidence: 99%

Pseudo-zwitterionic microvesicles for sustained urea release

Bibi

Kousar

Shah

et al. 2020

JSCS

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Zwitterionic microvesicles formed by catanionic system, based on sodium dodecyl sulfate and hexadecyltrimethyl ammonium bromide, have been investigated for sustained urea release using UV-visible absorption spectroscopy. The change in variables such as temperature, sonication time and initial urea concentration was related to urea entrapment efficiency and release from microvesicles. Korsmeyer-Peppas model was applied to highlight release mechanism and kinetics. Both diffusion and erosion were responsible for urea release and rate constant varied with change in conditions. The quantification of association between urea and catanionic vesicles in terms of binding constant (K bin) and binding free energy showed that urea binding was thermodynamically favored. Our results indicate that biocompatible pseudo-zwitterionic vesicles have enormous potential to act as sustained release system for nitrogenous fertilizers such as urea.

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Unique catanionic vesicles as a potential “Nano-Taxi” for drug delivery systems. In vitro and in vivo biocompatibility evaluation

Abstract: We evaluatein vitroandin vivotoxicity and stability in an acidic environment of new vesicles formed by the catanionic surfactant AOT-BHD in order to investigate their potential application as an oral drug delivery system.

Cited by 25 publications

References 51 publications

Amphiphilic ionic liquids as sustainable components to formulate promising vesicles to be used in nanomedicine

Amphiphilic ionic liquids as sustainable components to formulate promising vesicles to be used in nanomedicine

Effect of methanol on surfactants and surfactant–PEO mixtures

Pseudo-zwitterionic microvesicles for sustained urea release

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