Unique characteristics of local responses in host resistance to mucosal parasitic infections

Befus, Dean; Lee, T.; Ernst, Peter B.; Egwang, T G; McElroy, Paul J.; Gauldie, Jack; Bienstock, Jessica L.

doi:10.1016/0304-4017(86)90099-3

Cited by 12 publications

(5 citation statements)

References 62 publications

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“…These studies have allowed the identification of some of the functional properties of this isotype and indicated its participation in several mechanisms involved either in host defense or in pathological events (24). IgA antibodies were shown to inhibit antigen uptake (immune exclusion), to inhibit complement fixation, to stimulate cellular cytotoxicity, and to facilitate antigen clearance (2). In different parasitic diseases, IgA antibodies are associated with protection and participate in cytotoxicity and modulation of various cell types (6,7,13,14).…”

Section: The Immunoglobulin G (Igg) and Iga Antibody Responses To Difmentioning

confidence: 99%

Immunoglobulin A response in murine schistosomiasis: stimulatory role of egg antigens

et al. 1996

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The immunoglobulin G (IgG) and IgA antibody responses to different Schistosoma mansoni antigens have been determined in chronically infected mice as well as in unisexually infected animals. With a panel of enzyme-linked immunosorbent assays (ELISAs), soluble antigens from furcocercariae, adult worms, and eggs were probed with sera collected at 3-week intervals. Bisexually infected animals developed significant IgG and IgA antibody responses to the antigens tested, which increased after egg deposition. In unisexual infections no significant differences were recorded in the IgG antibody profile for furocercaria and adult worm antigens, whereas the IgA antibody response was impaired. Both the IgA and IgG antibody responses toward egg antigens were reduced compared with those in a bisexual infection. Furthermore, a specific mucosal IgA antibody response was observed only in the bisexually infected animals. Histological analysis performed on bisexually infected mice led to the observation of eggs and granulomatous lesions within the Peyer's patch follicles, which are essential sites for the induction of mucosal immunity in the intestine. These data suggest a relationship between egg deposition and the induction of the IgA antibody response toward schistosomes.

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Section: The Immunoglobulin G (Igg) and Iga Antibody Responses To Difmentioning

confidence: 99%

Immunoglobulin A response in murine schistosomiasis: stimulatory role of egg antigens

et al. 1996

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“…Correspondence: Dr M.D.Gorrell, Department of Veterinary Preclinical Sciences, The University of Melbourne, Park Drive, Parkville, Victoria, 3052,Australia. Smith et al (1984) have shown that lymphocytes leaving the abomasum of sheep immune to H. contortus can transfer immunity between monozygotic twins. Tlymphocytes are centrally involved in nematode expulsion (Miller 1984, Befus et al 1986 and their functions include the recruitment and regulation of mast cell differentiation (Haig, Jarrett & Tas 1984), and the recruitment of eosinophils (Sanderson, Warren & Strath 1985) and IgA-synthesizing plasma cells (Tomasi 1983). The study of mucosal lymphocytes is crucial for an understanding of immunity in the gut mucosa.…”

Section: Introductionmentioning

confidence: 99%

Lymphocyte phenotypes in the abomasal mucosa of sheep infected with Haemonchus contortus

Gorrell

Miller

Brandon

1988

Parasite Immunology

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Lymphocyte subpopulations in the abomasal mucosa of worm-free and parasitized sheep were assessed in situ. A preponderance of T-lymphocytes, with approximately equal numbers of cells expressing CD5, CD4 and CD8 antigens, was found. Most of the lymphocytes expressing CD8 lacked CD5. Using a panel of 15 monoclonal antibodies to ovine leucocyte antigens, abomasal lymphoid follicles in the mucosa were shown to resemble lymph node follicles phenotypically. Abomasal epithelial cells contained major histocompatibility complex (MHC) class II antigen. Infection or hyperimmunization of pasture-reared sheep with the gastric nematode Haemonchus contortus increased the numbers of mucosal mast cells and eosinophils but did not alter the phenotypic composition or number of mucosal lymphocytes or the pattern of expression of MHC class II antigens.

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“…NK cells are a subpopulation of lymphocytes in the peripheral blood and spleen that mediate nonspecific cytotoxicity against tumor cells, microbes, and microbially infected cells (13). Recently, increasing focus has been placed on the role of intestinal intraepithelial lymphocytes (IELs) in natural cellular resistance in response to infectious agents (1). Various studies have indicated that lymphocytes with NK cell activities are present in mammalian intestinal mucosa (6,7) as well as in the intestines of chickens (4).…”

mentioning

confidence: 99%

“…Various studies have indicated that lymphocytes with NK cell activities are present in mammalian intestinal mucosa (6,7) as well as in the intestines of chickens (4). IELs play an important role in local cellular resistance and are involved in the first line of host defense against invading microbes (1). In view of recent evidence that strain differences in disease resistance to coccidiosis may involve a cellular component rather than an antibody response (23), I investigated the local as well as splenic NK cell responses to Eimeria infections in SC and FP strains of chickens.…”

mentioning

confidence: 99%

Intestinal intraepithelial and splenic natural killer cell responses to eimerian infections in inbred chickens

Lillehoj¹

1989

Infect Immun

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Splenic and intestinal natural killer (NK) cell responses were assessed in chickens inoculated with Eimeria parasites. The NK cell activities of both splenic and intestinal intraepithelial lymphocytes (IELs) decreased to a subnormal level during the early phase of eimerian infections but returned to normal or slightly higher than normal levels at about 1 week after the primary inoculation. Lymphocytes obtained from the lamina propria did not show any detectable level of NK cell activity during or following eimerian infections. Significant increases in splenic and intestinal IEL NK cell activities were seen during the early phase of secondary infection. The increase in the IEL NK cell activity that was seen shortly following secondary eimerian infection was accompanied by a substantial increase in the number of IELs expressing the asialo-GM1 antigen. Host strain differences in both splenic and IEL NK cell responses were detected following primary eimerian infections. These results suggest that both splenic and intestinal IEL NK cells may play an important role in the host defense against intestinal protozoan infections.

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Unique characteristics of local responses in host resistance to mucosal parasitic infections

Cited by 12 publications

References 62 publications

Immunoglobulin A response in murine schistosomiasis: stimulatory role of egg antigens

Immunoglobulin A response in murine schistosomiasis: stimulatory role of egg antigens

Lymphocyte phenotypes in the abomasal mucosa of sheep infected with Haemonchus contortus

Intestinal intraepithelial and splenic natural killer cell responses to eimerian infections in inbred chickens

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