Unique Characteristics of Malignant Schneiderian Papilloma

Nachtigal, Dan; Yoskovitch, Adi; Frenkiel, Saul; Braverman, Itzhak; Rochon, Louise

doi:10.1053/hn.1999.v121.a98734

Cited by 30 publications

(39 citation statements)

References 30 publications

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“…The malignant alteration of IPs has been widely recognized [1,4,8,22,23,[42][43][44][59][60][61][62][63][64][65]. Of all carcinomas associated with IPs, 61% are synchronous and 39%, metachronous [66].…”

Section: Discussionmentioning

confidence: 99%

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

et al. 2011

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Inverted papillomas (IPs) are the most frequent type of sinonasal papillomas. These benign but destructive lesions are known for their high recurrence rate, probably due to incomplete excision. Our aim was to investigate the frequency of human papillomavirus (HPV) infection in patients with IPs and in IPs associated with squamous cell carcinoma (IPsSCC) and to compare it with the frequency of HPV infections in the control group. The influence of HPV infection on the malignant alteration and recurrence rate of IPs was also evaluated. Paraffin-embedded tissue samples from 68 patients with sinonasal IPs and 5 patients with IPsSCC were analyzed in this retrospective study. The control group consisted of 47 patients who had undergone septoplasty or mucotomy of the inferior turbinate. PCR amplification with consensus primer sets was performed to detect alpha-HPVs, and direct sequencing of the PCR products with the same primers was used to determine the HPV genotypes in the samples. We detected HPV DNA in 20 (30.3%) patients with IPs, in 3 (60%) patients with IPsSCC, and in 6 (13%) patients from the control group. The frequency of HPV infection in the study group was statistically significantly higher (p = 0.032) than in the control group. The presence of HPV DNA was not a statistically significant predictor of the recurrence of IPs (p = 0.745) nor was it a statistically significant risk factor for associated SCC (p = 0.32). Since HPV type 11 was the predominant genotype in the IPs, IPsSCC, and in the control cases, we presume that HPV infection may represent incidental colonization rather than being an important etiological factor of IPs.

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Section: Discussionmentioning

confidence: 99%

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

et al. 2011

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“…Malignancy was found to be associated with bilateral inverted papilloma, histologic multicentricity [521], a predominance of mature squamous epithelium, the presence of all three epithelial types (metaplastic squamous, mature squamous, and cylindrical), severe hyperkeratosis, a mitotic index greater than or equal to 2 per high-power field (HPF), absence of inflammatory polyps among the papillomas, an abundance of plasma cells, an absence of neutrophils, the presence of bone invasion, the absence of inflammatory polyp, increase in the ratio neoplastic epithelium : stroma, increase in hyperkeratosis, the presence of squamous epithelial hyperplasia, increase in the mitotic index, and a decrease in the number of eosinophils [511, 522]. Clinically benign behavior was related to the presence of inflammatory polyp and the absence of hyperkeratosis, predominantly mucinous tumors, a mitotic index less than 1 per HPF, a ratio of neoplastic epithelium/connective tissue stroma greater than or equal to 6, and the presence of inflammatory polyps among the papillomas [89, 511].…”

Section: Challenges and Complicationsmentioning

confidence: 99%

Skull Base Inverted Papilloma: A Comprehensive Review

2012

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Skull base inverted papilloma (IP) is an unusual entity for many neurosurgeons. IP is renowned for its high rate of recurrence, its ability to cause local destruction, and its association with malignancy. This paper is a comprehensive review of the reports, studies, and reviews published in the current biomedical literature from 1947 to September 2010 and synthesize this information to focus on its potential invasion to the base of the skull and possible intradural extension. The objective is to familiarize the clinician with the different aspects of this unusual disease. The role of modern diagnostic tools in medical imaging in order to assess clearly the limits of the tumors and to enhance the efficiency and the safety in the choice of a surgical approach is pointed out. The treatment guidelines for IP have undergone a complex evolution that continues today. Radical excision of the tumour is technically difficult and often incomplete. Successful management of IP requires resection of the affected mucosa which could be achieved with open surgery, endoscopic, or combined approach. Radio and chemotherapy were used for certain indications. More optimally research would be a multicenter randomized trials with large size cohorts.

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“…The rate of malignant transformation of IPs has ranged from 5% to 32%, being less than 10% in most series 16 23 24 26 28 29 30 31 32. The criteria for the diagnosis of in-situ and invasive squamous cell carcinoma arising or associated with IP are similar to those used for conventional squamous cell carcinoma arising in other regions of the head and neck.…”

Section: Schneiderian Papillomasmentioning

confidence: 99%

Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx

Perez-Ordoñez

2009

J Clin Pathol

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Lesions of the sinonasal tract are uncommon, with most of the specimens seen by surgical pathologists consisting primarily of fragments of inflamed sinonasal mucosa or inflammatory polyps from patients with chronic rhinosinusitis, and the occasional squamous cell carcinoma. Other lesions such as hamartomas, various types of Schneiderian papillomas and adenocarcinomas are seen only rarely by most histopathologists; therefore a biopsy or surgical resection specimen from a patient with one of these processes may represent a diagnostic challenge. The aim of this review is to present the pathological features of a group of infrequent epithelial surface and glandular lesions of the sinonasal tract which includes respiratory epithelial adenomatoid hamartoma, glandular (seromucinous) hamartoma, exophytic papilloma, inverted papilloma, cylindrical cell (oncocytic) papilloma, low-grade sinonasal adenocarcinoma and intestinal-type sinonasal adenocarcinoma.

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Unique Characteristics of Malignant Schneiderian Papilloma

Abstract: The physician evaluating a patient with SP should be aware of the features described and of their possible association with a malignant lesion.

Cited by 30 publications

References 30 publications

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

Skull Base Inverted Papilloma: A Comprehensive Review

Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx

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