1999
DOI: 10.1097/00006254-199908000-00020
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Unique Checkpoints During the First Cell Cycle of Fertilization After Intracytoplasmic Sperm Injection in Rhesus Monkeys

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Cited by 51 publications
(65 citation statements)
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“…With the intracytoplasmic sperm injection (ICSI) technique, uncapacitated spermatozoa with intact acrosomes are usually used to produce embryos, so the cholesterol-rich plasma membrane and acrosome enzymes are injected into the ooplasm. These spermatozoal structures have been suggested to affect sperm chromatin remodeling in mice [2], pigs [3] and rhesus monkeys [4][5][6]. While injection of uncapacitated spermatozoa with intact acrosomes affects development of mouse ICSI embryos [7], simultaneous removal of the plasma membrane and acrosome before ICSI improves embryonic development [8].…”
Section: Introductionmentioning
confidence: 99%
“…With the intracytoplasmic sperm injection (ICSI) technique, uncapacitated spermatozoa with intact acrosomes are usually used to produce embryos, so the cholesterol-rich plasma membrane and acrosome enzymes are injected into the ooplasm. These spermatozoal structures have been suggested to affect sperm chromatin remodeling in mice [2], pigs [3] and rhesus monkeys [4][5][6]. While injection of uncapacitated spermatozoa with intact acrosomes affects development of mouse ICSI embryos [7], simultaneous removal of the plasma membrane and acrosome before ICSI improves embryonic development [8].…”
Section: Introductionmentioning
confidence: 99%
“…In intracytoplasmic sperm injection (ICSI), a single spermatozoon is directly injected into the egg through the oocyte membrane. Studies on embryos from various mammalian species suggest that ICSI is related to a host of chromosomal abnormalities including effects on spindle apparatus, microtubules, chromatin behavior, cell cycle checkpoints, and chromosome positioning (Hewitson et al 1999;Luetjens et al 1999;Ramalho-Santos et al 2000;Sutovsky et al 1996;Terada et al 2000). Increases in both de novo sex chromosome abnormalities and de novo autosomal rearrangements have been reported among infants conceived using ICSI (Bonduelle et al 2002).…”
Section: Assisted Reproductive Technologiesmentioning
confidence: 99%
“…The ICSI technique has been reported for collecting embryos from in vitro in the cynomolgus monkey [67] and the rhesus monkey [33,34,64]. For example, my research group first used ICSI in cynomolgus monkeys [67], and we expect that this technique will achieve a fertilization rate higher than that for IVF.…”
Section: Intracytoplasmic Sperm Injection (Icsi)mentioning
confidence: 99%
“…Human offspring have already been obtained by intracytoplasmic injection of spermatid [22]. Although intracytoplasmic injection techniques are useful for preserving the male gene at the cellular level and seem to be a good possibility for gene manipulation as transgenic animals, the effectiveness and safety of the technique needs to be determined [33].…”
Section: Intracytoplasmic Sperm Injection (Icsi)mentioning
confidence: 99%