Unique Clone of<i>Coxiella burnetii</i>Causing Severe Q Fever, French Guiana

Mahamat, Aba; Edouard, Sophie; Demar, Magalie; Abboud, Philippe; Patrice, Jean-Yves; Scola, Bernard La; Okandze, Antoine; Djossou, Félix; Raoult, Didier

doi:10.3201/eid1907.130044

Cited by 45 publications

(39 citation statements)

References 14 publications

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“…Researchers hypothesize that this genotype is more likely to cause a subclinical infection that goes untreated, thereby persisting and causing chronic disease such as endocarditis [18]. Genotype 17 is associated with severe, acute Q fever pneumonia in French Guiana [19]. In the USA, millions of dairy cows appear exclusively infected with genotype 20 strains.…”

Section: Coxiella: a Wide-ranging Zoonotic Pathogenmentioning

confidence: 99%

Right on Q: Genetics begin to Unravel Coxiella Burnetii host cell Interactions

et al. 2016

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Invasion of macrophages and replication within an acidic and degradative phagolysosomelike vacuole are essential for disease pathogenesis by Coxiella burnetii, the bacterial agent of human Q fever. Previous experimental constraints imposed by the obligate intracellular nature of Coxiella limited knowledge of pathogen strategies that promote infection. Fortunately, new genetic tools facilitated by axenic culture now allow allelic exchange and transposon mutagenesis approaches for virulence gene discovery. Phenotypic screens have illuminated the critical importance of Coxiella's type 4B secretion system in host cell subversion and discovered genes encoding translocated effector proteins that manipulate critical infection events. Here, we highlight the cellular microbiology and genetics of Coxiella and how recent technical advances now make Coxiella a model organism to study macrophage parasitism.

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Section: Coxiella: a Wide-ranging Zoonotic Pathogenmentioning

confidence: 99%

Right on Q: Genetics begin to Unravel Coxiella Burnetii host cell Interactions

et al. 2016

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“…Moreover, genotype 17 harbors the QpH1 plasmid, which is present in clones that cause severe clinical forms of Q fever in animal models. 45 This finding result suggests that the severe initial presentation for patients with of Q fever pneumonia in this region is linked to this particular strain. All genotype 17 strains are susceptible to antibiotics, particularly doxycycline, suggesting that this drug remains a good first-line treatment for Q fever pneumonia in French Guiana.…”

Section: Microbiologic Featuresmentioning

confidence: 78%

“…We finally isolated five C. burnetii strains from biological samples of patients from Cayenne that were obtained during 2000-2012. 45 Two strains were isolated from patients with endocarditis, and the three other strains were isolated from patients with pneumonia. Genotyping of these strains was performed and identified all of them as genotype 17.…”

Section: Microbiologic Featuresmentioning

confidence: 99%

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Q Fever in French Guiana

Eldin¹,

Mahamat²,

Demar³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Coxiella burnetii, the causative agent of Q fever, is present worldwide. Recent studies have shown that this bacterium is an emerging pathogen in French Guiana and has a high prevalence (24% of community-acquired pneumonia). In this review, we focus on the peculiar epidemiology of Q fever in French Guiana. We place it in the context of the epidemiology of the disease in the surrounding countries of South America. We also review the clinical features of Q fever in this region, which has severe initial presentation but low mortality rates. These characteristics seem to be linked to a unique genotype (genotype 17). Finally, we discuss the issue of the animal reservoir of C. burnetii in French Guiana, which is still unknown. Further studies are necessary to identify this reservoir. Identification of this reservoir will improve the understanding of the Q fever epidemic in French Guiana and will provide new tools to control this public health problem.

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“…Ces formes sévères de la maladie sont liées à une seule et unique souche de C. burnetii circulant en Guyane, C. burnetii génotype MST 17. Cette souche est spécifique à la Guyane et a été isolée en culture puis séquencée pour la première fois en 2012, permettant la mise au point d'outils spécifiques de diagnostic en biologie moléculaire (Polymérase Chain Réaction -PCR) (Mahamat et al 2013;D'Amato et al 2015). Les réponses immunitaires à C. burnetii MST 17 sont marquées par des titres d'anticorps IgG de phase I très élevés .…”

Section: Caractéristiques Cliniques Et Microbiologiquesunclassified

Spécificités épidémiologiques de la fièvre Q en Guyane

Santi¹,

Marié²,

Briolant³

et al. 2016

bavf

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Les études scientifiques menées sur la fièvre Q en Guyane au cours des quinze dernières années ont permis de répondre à de nombreuses interrogations sur l’épidémiologie humaine et animale de cette maladie. Les résultats observés démontrent une réelle spécificité locale de la fièvre Q, avec une souche de Coxiella burnetii unique et hypervirulente, une transmission suburbaine et en bordure de forêt, principalement sur la ville de Cayenne et ses alentours, des formes pulmonaires prédominantes, un réservoir sauvage de la bactérie et la possibilité d’une transmission vectorielle par les tiques. La prévalence réelle de la maladie dans la population guyanaise reste inconnue et conditionne la mise en oeuvre d’une stratégie de santé publique dédiée. Cette communication se propose de faire une synthèse sur l’ensemble des connaissances acquises et sur les questions qui demeurent, dans une approche One Health.

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Unique Clone ofCoxiella burnetiiCausing Severe Q Fever, French Guiana

Cited by 45 publications

References 14 publications

Right on Q: Genetics begin to Unravel Coxiella Burnetii host cell Interactions

Right on Q: Genetics begin to Unravel Coxiella Burnetii host cell Interactions

Q Fever in French Guiana

Spécificités épidémiologiques de la fièvre Q en Guyane

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