Unique combination of anatomy and physiology in cells of the rat paralaminar thalamic nuclei adjacent to the medial geniculate body

Smith, Philip H.; Bartlett, Edward E.; Kowalkowski, Anna

doi:10.1002/cne.20913

Cited by 37 publications

(55 citation statements)

References 98 publications

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“…The existence of LTS bursting in identified Pf neurons has not been systematically tested in vivo, although most show a reduction or complete absence of I T and LTS bursting in vitro (Phelan et al, 2005;Smith et al, 2006) (but see Govindaiah and Cox, 2006), in accordance with our findings. Thus, CL neurons behave in a manner that is typical of thalamic relay neurons but Pf neurons do not, which challenges the common view that all relay cells have equivalent fundamental properties (Llinás and Steriade, 2006).…”

Section: Identified CL and Pf Neurons Have Different Firing Propertiesupporting

confidence: 88%

Novel and Distinct Operational Principles of Intralaminar Thalamic Neurons and Their Striatal Projections

Lacey¹,

Bolam²,

Magill³

2007

J. Neurosci.

145

140

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Neurons of the intralaminar thalamus, including central lateral (CL) and parafascicular (Pf) nuclei, innervate the cortex and striatum and are important for cognitive, sensory, and motor processes. We tested the hypothesis that CL and Pf neurons provide functionally distinct inputs to the striatum. We performed recordings of single CL and Pf neurons in anesthetized rats and, after juxtacellularly labeling the neurons, their somatodendritic features and synaptic connections were characterized.All CL neurons (n ϭ 31) discharged classic low-threshold Ca 2ϩ spike bursts during cortical slow-wave activity in vivo. In contrast, Pf neurons (n ϭ 52) rarely fired such bursts, but instead discharged groups of spikes at relatively low frequencies. The activity of CL and Pf neurons was often temporally coupled to cortical slow oscillations. Identified CL neurons possessed archetypal "bushy" dendrites and preferentially established synapses with dendritic spines (91% of synapses) of striatal projection neurons. Pf neurons possessed "reticular-like" dendrites, and, on average, preferentially established synapses with dendritic shafts (63%) in striatum, although connectivity was markedly heterogeneous across neurons. Two of the six Pf neurons studied exclusively targeted dendritic shafts, whereas another neuron almost exclusively (97%) targeted spines. The remaining three neurons preferentially targeted dendritic shafts (53-70%).Thus, the fundamental properties of CL and Pf neurons differ (the latter do not express the typical operational principles of thalamic relay neurons), and they provide different temporally patterned inputs to distinct striatal targets. This mechanistic diversity likely underpins the transmission of specific and discrete information from intralaminar thalamic nuclei to striatal and cortical targets.

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Section: Identified CL and Pf Neurons Have Different Firing Propertiesupporting

confidence: 88%

Novel and Distinct Operational Principles of Intralaminar Thalamic Neurons and Their Striatal Projections

Lacey¹,

Bolam²,

Magill³

2007

J. Neurosci.

145

140

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“…More recent studies suggest that the so-called suprageniculate nucleus considered classically as a subdivision of the MGD Coleman, 1990, 1998;Winer et al, 1999bWiner et al, , 1996c may be a distinct MG division (Kimura VI. SYSTEMS et al, 2003, 2007a, 2007bHazama et al, 2004;Smith et al, 2006Smith et al, , 2007Storace et al, 2010Storace et al, , 2011Storace et al, , 2012. Physiological studies have showed that the caudal part of the Rt (Fig.…”

Section: The Medial Geniculate Bodymentioning

confidence: 96%

“…The thalamic nuclei surrounding the MG in the adjacent posterior, medial and rostral parts to the MG proper constitute the caudal paralaminar nuclei ( Fig. 3; Herkenham, 1980;Linke, 1999aLinke, , 1999bSmith et al, 2006Smith et al, , 2007, which play a key role in the acquisition of a conditioned emotional response to an acoustic stimulus (LeDoux et al, 1983;LeDoux, 1995). Finally, it is worth mentioning that recently Mitrofanis (2002) has discovered an auditory area in the zona incerta of the thalamus.…”

Section: The Medial Geniculate Bodymentioning

confidence: 97%

Auditory System

Malmierca

2015

The Rat Nervous System

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“…To determine the location of each cell, we used the electrode tracks for guidance, the point of entrance in the thalamus, the blue spot of pontamine sky-blue at the bottom of the track, and the depth coordinates read from the microdrive during the experiment. The assignment of each recorded cell to the different MG divisions was based on previously published anatomical descriptions of the rat MG (Clerici and Coleman 1990a,b;Doron and Ledoux 1999;Ledoux et al 1987;Smith et al 2006;Winer et al 1999). Determination of the location of the recording sites was done blind of the electrophysiological results.…”

Section: Histologymentioning

confidence: 99%

Tonotopic Control of Auditory Thalamus Frequency Tuning by Reticular Thalamic Neurons

Cotillon-Williams¹,

Huetz²,

Hennevin³

et al. 2008

Journal of Neurophysiology

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Cotillon-Williams N, Huetz C, Hennevin E, Edeline J-M. Tonotopic control of auditory thalamus frequency tuning by reticular thalamic neurons. J Neurophysiol 99: 1137-1151, 2008. First published December 26, 2007 doi:10.1152/jn.01159.2007. GABAergic cells of the thalamic reticular nucleus (TRN) can potentially exert strong control over transmission of information through thalamus to the cerebral cortex. Anatomical studies have shown that the reticulothalamic connections are spatially organized in the visual, somatosensory, and auditory systems. However, the issue of how inhibitory input from TRN controls the functional properties of thalamic relay cells and whether this control follows topographic rules remains largely unknown. Here we assessed the consequences of increasing or decreasing the activity of small ensembles of TRN neurons on the receptive field properties of medial geniculate (MG) neurons. For each MG cell, the frequency tuning curve and the rate-level function were tested before, during, and after microiontophoretic applications of GABA, or of glutamate, in the auditory sector of the TRN. For 66 MG cells tested during potent pharmacological control of TRN activity, group data did not reveal any significant effects. However, for a population of 20/66 cells (all but 1 recorded in the ventral, tonotopic, division), the breadth of tuning, the frequency selectivity and the acoustic threshold were significantly modified in the directions expected from removing, or reinforcing, a dominant inhibitory input onto MG cells. Such effects occurred only when the distance between the characteristic frequency of the recorded ventral MG cell and that of the TRN cells at the ejection site was Ͻ0.25 octaves; they never occurred for larger distances. This relationship indicates that the functional interactions between TRN cells and ventral MG cells rely on precise topographic connections. I N T R O D U C T I O NThe thalamus is often considered as a "gate" for the transfer of information to neocortex. Understanding the key factors controlling this gate has been the subject of intense research, but several points remain unresolved. The reticular nucleus of the thalamus (TRN) has a key anatomical position and chemical composition to modulate thalamocortical activity. It receives inputs from both thalamus and cortex and sends outputs back to the thalamus (Jones 1975). Exclusively composed of GABAergic neurons (Arcelli et al. 1997; Benson et al. 1991;Houser et al. 1980), it is a major source of inhibition for all thalamic nuclei . In some species and for some sensory modalities, it is the quasi-exclusive source of inhibition in the thalamus, whereas in others it shares this role with local inhibitory interneurons (reviewed in Jones 1985; Sherman and Guillery 2001). The lateral geniculate nucleus possesses around 20% of inhibitory interneurons in all species (Barbaresi et al. 1986; Benson et al. 1992). The somatosensory thalamus and the auditory thalamus possess 20 -25% of inhibitory interneurons in primate and cat (Benson e...

show abstract

Unique combination of anatomy and physiology in cells of the rat paralaminar thalamic nuclei adjacent to the medial geniculate body

Cited by 37 publications

References 98 publications

Novel and Distinct Operational Principles of Intralaminar Thalamic Neurons and Their Striatal Projections

Novel and Distinct Operational Principles of Intralaminar Thalamic Neurons and Their Striatal Projections

Auditory System

Tonotopic Control of Auditory Thalamus Frequency Tuning by Reticular Thalamic Neurons

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