Unique database study linking gingival inflammation and smoking in carcinogenesis

Söder, Birgitta; Andersson, Leif C.; Meurman, Jukka H.; Söder, Per‐Östen

doi:10.1098/rstb.2014.0041

Cited by 10 publications

(5 citation statements)

References 26 publications

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“…This finding was unexpected as both different subtypes of cancers, rheumatic and neurological diseases such as Alzheimer’s and depression have been linked to periodontitis ( Michaud et al, 2017 ; Nwizu et al, 2020 ; Kavarthapu and Gurumoorthy, 2021 ; Tuominen and Rautava, 2021 ; Zheng et al, 2021 ; Asher et al, 2022 ). Furthermore, the finding is not in line with our earlier research ( Söder et al, 2015 ). However, the present results only represent the sample here used and do not necessarily give the full picture of the whole cohort.…”

Section: Discussioncontrasting

confidence: 99%

Periodontitis may predict the use of prescription medicines later in life, a database study

et al. 2023

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Medications used for the treatment of diseases also affect oral health. We investigated how having/not having periodontitis at baseline in 1985 was associated with purchases of medicines in the long term. The study paradigm is in the oral health-systemic health connections. We hypothesized that periodontitis links to purchases of medicines later in life. The study cohort consisted of 3,276 individuals from the greater Stockholm area, Sweden. Of them, 1,655 were clinically examined at baseline. Patients were followed-up for >35 years, using the national population and patient registers. The burden of systemic diseases and purchases of medicines were statistically analyzed comparing patients with (n = 285) and without (n = 1,370) periodontitis. The results showed that patients with periodontitis had purchased more of certain medications than non-periodontitis patients. Periodontitis patients purchased significantly more drugs used in diabetes (p = 0.035), calcium channel blockers (p = 0.016), drugs acting on the renin-angiotensin system (p = 0.024), and nervous system drugs (p = 0.001). Hence, patients with periodontitis indeed had purchased specific medications statistically significantly more than the periodontally healthy ones. This indicates that periodontitis, over time, might increase the risk for systemic diseases with the subsequent need for medication.

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Section: Discussioncontrasting

confidence: 99%

Periodontitis may predict the use of prescription medicines later in life, a database study

et al. 2023

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“…In a 26-year follow-up data of The Stockholm Study cohort, gingival inflammation as assessed by a high GI score appeared to link to cancer in general. As expected, pack-years of smoking was a principal independent predictor with OR 1.32 (CI 1.05-1.67) while gingival inflammation gave an OR 1.29 (1.00-1.65), respectively, in multiple logistic regression analysis with cancer as the dependent variable and several independent variables in this cohort [30].…”

Section: Studies On Oral Infections and Cancersupporting

confidence: 79%

The Stockholm Study: Over 30 years’ Observation of the Effect of Oral Infections on Systemic Health

Meurman

Söder

2022

Dentistry Journal

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The Stockholm Studies are a series of investigations started in 1985 and still ongoing. Out of 105,798 inhabitants, aged 30 and 40 years and living in the greater Stockholm area in Sweden, 3273 subjects were randomly selected. Of them, 1676 were clinically examined focusing on oral health. The subjects were then followed up using national population and health registers in order to study associations between oral health parameters and systemic health outcomes and finally death. The 35 years of observation provides unique possibilities to analyze, for example, how periodontitis links to a number of systemic health issues. The results have consequently provided numerous new associations and confirmed earlier observations on how poor oral health is associated with heart diseases and cancer.

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“…The highly prevalent oral infections represent a huge inflammatory burden, both at the individual and population level, associating with a number of systemic diseases. Cardiovascular diseases, malignancies, diabetes, and even death, are indeed statistically linked to oral infections, particularly associating with periodontal disease [2][3][4][5]. We have earlier shown, in our ongoing register study the association of periodontal diseases to different kinds of cancer [4,6,7].…”

Section: Introductionmentioning

confidence: 77%

Periodontal microorganisms and diagnosis of malignancy: A cross-sectional study

Söder

Källmén

Yucel‐Lindberg

et al. 2021

TUB

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BACKGROUND: Oral infections associate statistically with cancer. OBJECTIVE: We hypothesized that certain periodontal microorganisms might specifically link to malignancies in general and set out to investigate this in our ongoing cohort study. METHODS: A sample of 99 clinically examined patients from our cohort of 1676 subjects was used to statistically investigate the associations between harboring periodontal microorganisms Aggregatibacter actinomycetemcomitans (A.a), Porphyromonas gingivalis (P.g), Prevotella intermedia (P.i), Tannerella forsythia (T.f) and Treponema denticola (T.d). We used oral infection indexes and the incidence figures of malignancies as registered in 2008–2016 in the Swedish National Cancer Register. RESULTS: The pathogen A.a showed strong association with malignancy in 32 out of the 99 patients while P.g and P.i were more prevalent among patients without malignancy. In principal component analyses, A.a appeared in the strongest component while the second strongest component consisted of a combination of T.f and T.d. The third component consisted of a combination of P.g and P.i, respectively. Of basic and oral health variables, gingival index appeared to be the strongest expression of inflammation (Eigen value 4.11 and Explained Variance 68.44 percent). CONCLUSIONS: The results partly confirmed our hypothesis by showing that harboring certain periodontal bacteria might link to malignancy. However, the associations are statistical and no conclusions can be drawn about causality.

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Unique database study linking gingival inflammation and smoking in carcinogenesis

Cited by 10 publications

References 26 publications

Periodontitis may predict the use of prescription medicines later in life, a database study

Periodontitis may predict the use of prescription medicines later in life, a database study

The Stockholm Study: Over 30 years’ Observation of the Effect of Oral Infections on Systemic Health

Periodontal microorganisms and diagnosis of malignancy: A cross-sectional study

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