Unique Effects of Mycophenolate Mofetil on Cord Blood T Cells

Derniame, Sophie; Lee, Fuiyee; Domogala, Anna; Madrigal, J. Alejandro

doi:10.1097/01.tp.0000438203.19595.3f

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…However, most animal models of transplantation rely solely on radiation-based conditioning. Therefore, effective translation will require validation of observations made in animal models with clinical cohorts, because standard immunesuppressing agents were shown to affect cytokine levels produced by T cells and NK cells, and profiles vary with stem cell source (80,81). Importantly, IFN-g, TNF, and IL-1 are not systemically dysregulated in clinical subjects after BMT who receive immune suppression in the same way as seen in rodent models (45).…”

Section: Translational Applicationmentioning

confidence: 99%

Cytokines in Graft-versus-Host Disease

Henden

Hill

2015

The Journal of Immunology

153

117

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Graft-versus-host disease (GVHD) is a complication of allogeneic bone marrow transplantation whereby transplanted naive and marrow-derived T cells damage recipient tissue through similar mechanisms to those that allow destruction of malignant cells, the therapeutic intent of bone marrow transplantation. The manifestations and severity of GVHD are highly variable and are influenced by the proportions of naive cells maturing along regulatory T cell, Th1, Th2, or Th17 phenotypes. This maturation is largely influenced by local cytokines, which, in turn, activate transcription factors and drive development toward a dominant phenotype. In addition, proinflammatory cytokines exert direct effects on GVHD target tissues. Our knowledge of the role that cytokines play in orchestrating GVHD is expanding rapidly and parallels other infective and inflammatory conditions in which a predominant T cell signature is causative of pathology. Because a broad spectrum of cytokine therapies is now routinely used in clinical practice, they are increasingly relevant to transplant medicine.

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Section: Translational Applicationmentioning

confidence: 99%

Cytokines in Graft-versus-Host Disease

Henden

Hill

2015

The Journal of Immunology

153

117

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“…T-reg cells are known to prevent and reduce GVHD. However, the response of different T-reg cells (activated or resting, donor or host derived) to MMF might differ and is not well understood [19] . The above mentioned immune dysregulations caused by MMF might have impaired the host's functional T-cell response (more than the donor's).…”

Section: Discussionmentioning

confidence: 99%

Isolated intestinal manifestation of graft-versus-host disease following renal transplantation

Praktiknjo

Boes

Majores

et al. 2014

CRIM

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Graft-versus-host disease (GVHD) is a potentially lethal complication commonly occurring after hematopoietic stem cell transplantation and non-irradiated blood cell transfusion in patients with underlying immunodeficiency. In solid organ transplantation GVHD however is a rarity. There have been four cases of GVHD after renal transplantation, most of them with fulminant systemic clinical manifestation and mostly associated with blood transfusions. We report the first case of a four HLA-antigen mismatched kidney transplant patient who presented with diarrhea due to intestine-only manifestation of GVHD and was treated successfully with quadruple immunosuppression.

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