Unique features of gastric carcinoma in the young

Theuer, Charles P.; Kurosaki, Tom; Taylor, Thomas H.; Anton‐Culver, Hoda

doi:10.1002/(sici)1097-0142(19980701)83:1<25::aid-cncr4>3.0.co;2-d

Cited by 76 publications

(66 citation statements)

References 38 publications

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“…Features reported more frequently in young patients compared with old patients included female predominance, a significantly higher proportions of Lauren's diffuse-type cancers amongst all tumor types, and poorly differentiated histologic tumor types [15][16][17]. Although some studies have analyzed GC characteristics in young patients [10][11][12], there are currently no reported studies that evaluated GC in extremely young adult patients aged 30 years or younger. Thus, little is known regarding predictors of GC survival for this group or for the subgroups who underwent resection.…”

Section: Introductionmentioning

confidence: 85%

“…These features include a predominance of female patients, genetics, and undifferentiated and diffuse histologic tumor types [12,16,22]. In the present study, we identified clinical and Fig.…”

Section: Discussionmentioning

confidence: 99%

“…However, there has been some concern about a trend toward steadily increasing GC in young patients over the past few decades and studies were conducted to define the demographic, clinicopathologic and prognostic factors of GC in young patients [10][11][12]. The incidence of GC in patients aged 40 years or younger ranges from 4.6 to 6.2 % [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

et al. 2014

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Background There is little known about the clinicopathological features and the predictors of survival in extremely young adult patients aged 18-30 years. The aim of this study was to identify clinicopathological features and clinical outcomes for the overall population and for a resectable subgroup of gastric cancer patients aged 18-30 years.Methods From January 2004 to December 2010, 207 patients aged between 18 and 30 years old were diagnosed with gastric cancer and treated at the Asan Medical Center. Clinical findings, histopathological parameters and outcomes were reviewed retrospectively. Patients were further divided into 2 groups according to tumor resectability and then clinicopathological factors that affect tumor resectability and clinical outcomes were analyzed. Results Clinicopathological characteristics of study population showed a predominance of females, undifferentiated tumors, diffuse-type cancers, and advanced gastric cancer. The overall resectability rate was 70.0 % and the median follow-up period was significantly longer in the resectable tumor group (P \ 0.001). Significant prognostic predictors for overall survival in overall patients were higher CEA levels (P = 0.016), larger tumor size (P \ 0.001), unresectability (P = 0.006), and presence of lymphovascular invasion (P = 0.012) in a multivariate analysis. Significant prognostic factors for overall survival in patients with resectable disease included larger tumor size ([4 cm), lymphovascular invasion and higher CEA level in the multivariate analysis. Conclusions Gastric adenocarcinomas in young adult patients aged 18-30 years have unique clinicopathological features. Early detection in a resectable state and subsequent complete resection could increase survival period in young patients with gastric cancer.

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Section: Introductionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

et al. 2014

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“…GC is usually diagnosed in the sixth and seventh decades of life, although it may also be found in younger patients. The incidence of GC in subjects 40 years of age or younger is very low and ranges between 2 and 15% [2][3][4]. The clinicopathological characteristics of GC in elderly patients have been extensively discussed in the literature.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological profile and long-term outcome in young adults with gastric cancer: multicenter evaluation of 214 patients

Kulig

Popiela

Kołodziejczyk

et al. 2007

Langenbecks Arch Surg

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“…Gastric cancer primarily occurs in patients over 50 years of age. The described proportion of young patients with gastric cancer varies from 2% to 15% depending on the age defined as young [14,15] . Female patients have a relative dominance in this group and the incidence of gastric cancer is higher in women over the age of 30 years.…”

Section: Discussionmentioning

confidence: 99%

Sister Mary Joseph’s nodule as the first sign of pregnancy-associated gastric cancer: A case report

Fill

Taran²,

Schulz³

et al. 2008

WJG

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Sister Mary Joseph's nodule is an inconspicuous and uncommon clinical sign of advanced malignant disease, especially gastric cancer. Pregnancy-associated gastric cancer is an extremely rare condition and can be difficult to diagnose, due to the absence or misinterpretation of symptoms as pregnancy-related. Diagnostic aids, such as a basic chemistry panel and imaging techniques, may not show any abnormalities. We present a case of a 37-yearold pregnant patient whose umbilical nodule was the first presenting physical sign of gastric cancer, which had metastasized throughout the abdominal and pelvic regions.

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Unique features of gastric carcinoma in the young

Cited by 76 publications

References 38 publications

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

Clinicopathological profile and long-term outcome in young adults with gastric cancer: multicenter evaluation of 214 patients

Sister Mary Joseph’s nodule as the first sign of pregnancy-associated gastric cancer: A case report

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