Unique green chromatographic method for the qualitative and quantitative analysis of ketoconazole, its impurities and preservatives from ketoconazole cream formulation: Identification of degradants by Q-ToF LCMS and Robustness by Design of Experiments

An integrated framework to develop an efficient valid green (EVG) HPLC method for the assessment of antimicrobial pollutants with potential threats to human health in aquatic systems

“…The AGREE meter is a comprehensive greenness tool that represents an analytical method by a colored pictogram divided into 12 principles, where each principle describes an environmental criterion by a color ranging from deep green (highest) to deep red (lowest); the overall score ranging from zero to the highest score of one is in the middle. 37,[57][58][59] As previously mentioned, only LC-MS was reported for the analysis of these drugs simultaneously; thus, the proposed method was compared to reported HPLC-UV methods for the simultaneous quantitation of two drugs, CIP and SMZ, 36 as well as CIP and ALB. 28 The AGREE pictogram of the proposed method was altered to a greener color with a higher score of (0.55) compared to other reported methods.…”