Unique Inbred Strain MSM/Ms Established from the Japanese Wild Mouse

Moriwaki, Kazuo; Miyashita, Nobumoto; Mita, Akihiko; Gotoh, Hiroki; Tsuchiya, Koichiro; Kato, Hideki; Mekada, Kazuyuki; Noro, Chikako; Oota, Satoshi; Yoshiki, Atsushi; Obata, Yuichi; Yonekawa, Hiromichi; Shiroishi, Toshihiko

doi:10.1538/expanim.58.123

Cited by 52 publications

(56 citation statements)

References 28 publications

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“…In addition to C3H and B6J strains, we examined MSM/Ms inbred strain (MSM), which was recently established from wild mice, Mus musculus molossinus, and retains many traits of wild mice (14). MSM mice produced melatonin during nighttime with a peak just before the light came on (Fig.…”

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confidence: 99%

Genetic variation of melatonin productivity in laboratory mice under domestication

Kasahara

Abe²,

Mekada

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Melatonin is a pineal hormone produced at night; however, many strains of laboratory mice are deficient in melatonin. Strangely enough, the gene encoding HIOMT enzyme (also known as ASMT) that catalyzes the last step of melatonin synthesis is still unidentified in the house mouse (Mus musculus) despite the completion of the genome sequence. Here we report the identification of the mouse Hiomt gene, which was mapped to the pseudoautosomal region (PAR) of sex chromosomes. The gene was highly polymorphic, and nonsynonymous SNPs were found in melatonin-deficient strains. In C57BL/6 strain, there are two mutations, both of which markedly reduce protein expression. Mutability of the Hiomt likely due to a high recombination rate in the PAR could be the genomic basis for the high prevalence of melatonin deficiency. To understand the physiologic basis, we examined a wild-derived strain, MSM/Ms, which produced melatonin more under a short-day condition than a long-day condition, accompanied by increased Hiomt expression. We generated F2 intercrosses between MSM/ Ms and C57BL/6 strains and N2 backcrosses to investigate the role of melatonin productivity on the physiology of mice. Although there was no apparent effect of melatonin productivity on the circadian behaviors, testis development was significantly promoted in melatonin-deficient mice. Exogenous melatonin also had the antigonadal action in mice of a melatonin-deficient strain. These findings suggest a favorable impact of melatonin deficiency due to Hiomt mutations on domestic mice in breeding colonies.

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confidence: 99%

Genetic variation of melatonin productivity in laboratory mice under domestication

Kasahara

Abe²,

Mekada

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

172

161

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“…The activities are not uniform even among wild-derived mice. In a comparison of KoR1/Stm, KoR5/Stm, and KoR7/Stm from Koriyama with MSM/Ms from Mishima, Shizuoka Prefecture, we found that the activity of MSM, in particular, the vertical jumping ability, was greater than that of other strains [17]. These behavioral activities are generally polygenic traits; therefore, mice with varied origin may provide tools for the study of the genetic control of behavior.…”

Section: Wild Mice In the Tohoku Areamentioning

confidence: 85%

Japanese Wild Mice: A Rich Resource for New Disease Models

Matsushima

2012

Exp. Anim.

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Abstract:Breeding of fancy mice has been a tradition in Japan. Recent progress in animal science has shed a new light on Japanese wild-derived mice as tools for discovery of new disease models because these mice, Mus musculus molossinus, are genetically far remote from the majority of available laboratory mice. After decades of effort, five inbred strains of mice have been established from pairs of wild mice trapped in Tohoku, northeastern Japan, namely KOR1/Stm, KOR5/Stm, KOR7/Stm, AIZ/Stm, and MAE/Stm. They carried numerous mutations, leading to a variety of diseases. During the inbreeding of KOR1, the first spontaneous mutation was found in the Apoe (apolipoprotein E) gene, and the mutant was later designated as spontaneous hyperlipidemic (SHL). Thereafter, a number of other mutations were discovered among wild-derived inbred strains, including atopic dermatitis, microphthalmia, dominant white spots, sebaceous gland abnormalities, and audible song-like vocalization. Furthermore, to examine the possible effects of the genetic background for these mutant genes, sets of congenic strains were generated, in which the mutant gene was introduced into at least 3 different strains of laboratory mice, including BALB/c and C57BL/6. These congenic strains have now been established as novel disease models. These wildderived inbred strains serve as a treasure trove for novel disease models. Most of them have been deposited in the Riken BioResource Center (BRC), and some are also available from commercial breeders.

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“…The MSM line originated from Japanese wild mice, Mus musculus molossinus (Moriwaki et al, 2009), and maintains a very large amount of genetic diversity in the genome (Kikkawa et al, 2001, Sakai et al, 2005, Takada et al, 2008a compared with other classical inbred strains, such as BALB/c and C57BL/6, and we often use the MSM strain to perform finer genetic mapping. This analysis led to two important observations: 1) the occurrence of dermatitis is not associated with an elevated serum IgE level (Kohara et al unpublished); and 2) the major locus responsible for dermatitis (the derm1 locus) is located on the middle of chromosome 9 (Fig.…”

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confidence: 99%