Unique inflammatory signature in haemophilic arthropathy: miRNA changes due to interaction between blood and fibroblast‐like synoviocytes

Abstract

Haemophilia is an X-linked bleeding disease caused by a partial or complete deficiency of coagulation factor VIII or IX. 1 Bleeding mainly occurs in large joints, such as the knee, elbow or ankle, as a result of inadequate thrombin generation due to the lack of a clotting factor. 2 Recurring hemarthrosis leads to an irreversible arthropathy, termed haemophilic arthropathy (HA), characterized by a progressively complete destruction of the joint with permanent pain,

Potential role of long non‐coding RNA H19 and Neat1 in haemophilic arthropathy

“…22 Interestingly, these lncRNAs have also been extensively investigated for their role in multiple cancer types, 23 suggesting their link to the proliferative phenotype seen in synovial hyperplasia and cartilage turnover. Nonetheless, the pathobiology of haemophilic arthropathy is primarily influenced by blood induced joint inflammation and cartilage degradation, 24 and a detailed spatio-temporal profiling may be necessary to completely understand the effect of lncRNA deregulation and its hitherto unknown roles in joint disease. Since many of these lncRNAs and associated pathways are conserved, 25 this knowledge can benefit a variety of other joint diseases such as RA and OA.…”