Unique Novel Role of Adropin in a Gastric Ulcer in a Rotenone-Induced Rat Model of Parkinson’s Disease

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disease, frequently associated with a gastric ulcer. We aimed to investigate the adropin neuroprotective/gastroprotective potential in the indomethacin (IND)-induced gastric ulcer in a rotenone-induced PD model. Rats were randomly divided into four groups: normal control group, rotenone/IND treated (PD /Ulcer) group, adropin treated PD/Ulcer group, and l-dopa/omeprazole (Om) treated PD/Ulcer group. There were ten rats selected for the normal control group. Striatal dopamine (DA), apoptosis/redox status, and motor/behavioral impairments were evaluated. Gastric oxidative stress, H+/K+-ATPase activity, prostaglandin E2, mucin content, and von Willebrand factor were measured. Gastric/striatal phosphatidylinositol 3-kinase (PI3K)/phosphorylated Akt and gastric vascular endothelial growth factor (VEGF)/striatal P53 immunoreactivities were checked. Striatal P53 upregulated modulator of apoptosis (Puma)/gastric vascular endothelial growth factor receptor-2 (Vegfr-2) expressions were evaluated. Adropin successfully restored striatal DA and attenuated rotenone-induced motor/behavior deficits along with strong gastroprotective potential, possibly through antioxidant activity via reduction in malondialdehyde level and upregulated superoxide dismutase, catalase activities, and serum ferric reducing antioxidant power. Adropin restored the delicate balance between the defective pro-survival PI3K/Akt/murine double minute 2 signals and apoptotic P53/Puma pathways. Adropin can be considered as a uniquely attractive therapeutic target in PD and its associated gastric ulcer.

Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1

“…2.8.2 | Assay of testicular malondialdehyde and 8-hydroxy-2 0 -deoxyguanosine (8-OHdG) Malondialdehyde, as a marker of lipid peroxidation, was estimated at wavelength 532 nm and expressed as nmolÁmg À1 protein (Abo El Gheit et al, 2020). 8-OHdG, a marker of oxidative DNA damage, was estimated by 8-OHdG Check ELISA kit (Cat# #KOG-HS10E, JaICA, Shizuoka, Japan).…”

Circulating levels of adropin and diabetes: a systematic review and meta-analysis of observational studies

“…Of the 671 retrieved studies, 261 remained after duplicates removed, and 72 remained after title/abstract screening. A total of 62 studies were excluded after screening the full-texts for the following reasons: nondiabetic patients (n = 32) [25,, without reference group (n = 1) [17], animal model (n = 19) [7,23,[65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81], cell studies (n = 4) [12,[82][83][84], and randomized trials (n = 6) [85][86][87][88][89][90]. Update search on the 13th of August 2022, yielded additional five eligible studies.…”

Effect of Adropin on Pancreas Exocrine Function in a Rat Model: A Preliminary Study

“…It is limited to a few reports. The gastroprotective potential of ADR was demonstrated in rats with indomethacin-induced gastric ulcers [ 18 ]. On the one hand, the ADR treatment reduced the activity of the gastric proton pump and the malondialdehyde level, but on the other hand, it upregulated superoxide dismutase and catalase activities.…”

“…On the one hand, the ADR treatment reduced the activity of the gastric proton pump and the malondialdehyde level, but on the other hand, it upregulated superoxide dismutase and catalase activities. Moreover, ADR increased the content of gastric mucosal mucin, gastric PGE2, and VEGF cytoplasmic immunoreaction in the gastric mucosa and promoted Vegfr-2 expression [ 18 ].…”