Unique product quality considerations in vaccine development, registration and new program implementation in Malaysia

Khoo, Yvonne Siew Khoon; Ghani, Abd; Navamukundan, A. A.; Jahis, Rohani; Gamil, Abdrhman Mahmoud

doi:10.1080/21645515.2019.1667206

Cited by 31 publications

(31 citation statements)

References 25 publications

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“…A recent study conducted in Malaysia on vaccine development showed their willingness towards trusting ‘halal’ vaccines. Malay Muslim children’s parents have expressed concerns regarding the vaccine ingredients’ halal state because they believe that imported vaccines might be composed of porcine-derived agents, such as deoxyribonucleic acid (DNA), which is not halal, as the utilization of porcine-sourced products, including medicines, is generally not permissible for Muslims [ 36 ]. For vaccination against SARS-CoV-2, similar concerns arose in Indonesia [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccination Intent and Willingness to Pay in Bangladesh: A Cross-Sectional Study

Kabir

Mahmud

Chowdhury³

et al. 2021

Vaccines

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This article reports the intent to receive a SARS-COV-2 vaccine, its predictors and willingness to pay in Bangladesh. We carried out an online cross-sectional survey of 697 adults from the general population of Bangladesh in January 2021. A structured questionnaire was used to assess vaccination intent. The questionnaire included sociodemographic variables and health belief model constructs which may predict vaccination intent. Among the participants, 26% demonstrated a definite intent, 43% probable intent, 24% probable negative, and 7% a definite negative intention. Multivariable logistic regression analyses suggest an association between definite intent and previous COVID-19 infection (OR: 2.86; 95% CI: 1.71–4.78), perceiving COVID-19 as serious (OR: 1.93; 1.04–3.59), the belief that vaccination would make them feel less worried about catching COVID-19 (OR: 4.42; 2.25–8.68), and concerns about vaccine affordability (OR: 1.51; 1.01–2.25). Individuals afraid of the side effects (OR: 0.34; 0.21–0.53) and those who would take the vaccine if the vaccine were taken by many others (OR: 0.44; 0.29–0.67) are less likely to have a definite intent. A definite negative intent is associated with the concern that the vaccine may not be halal (OR: 2.03; 1.04–3.96). Furthermore, 68.4% are willing to pay for the vaccine. The median amount that they are willing to pay is USD 7.08. The study findings reveal that the definite intent to receive the SARS-CoV-2 vaccination among the general population varies depending on their COVID-19-related health beliefs and no significant association was found with sociodemographic variables.

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Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccination Intent and Willingness to Pay in Bangladesh: A Cross-Sectional Study

Kabir

Mahmud

Chowdhury³

et al. 2021

Vaccines

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show abstract

“…Ultimately, more qualitative studies are required in the African setting to decipher and address possible causes of COVID-19 vaccine hesitancy [ 23 ]. It is worth noting that in Somalia as in other Muslim nations, the ‘halal’ nature of any vaccine is of prime importance [ 24 ]. This explains why concerns were raised regarding the use of porcine derivatives when manufacturing COVID-19 vaccines.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccine Acceptability and Adherence to Preventive Measures in Somalia: Results of an Online Survey

et al. 2021

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Most countries are currently gravitating towards vaccination as mainstay strategy to quell COVID-19 transmission. Between December 2020 and January 2021, we conducted a follow-up online survey in Somalia to monitor adherence to COVID-19 preventive measures, and COVID-19 vaccine acceptability and reasons for vaccine hesitancy. Adherence was measured via a composite adherence score based on four measures (physical distancing, face mask use, hand hygiene, and mouth covering when coughing/sneezing). We analyzed 4543 responses (mean age: 23.5 ± 6.4 years, 62.4% males). The mean adherence score during this survey was lower than the score during a similar survey in April 2020. A total of 76.8% of respondents were willing to receive the COVID-19 vaccine. Flu-like symptoms were more frequently reported in the current survey compared to previous surveys. Multiple logistic regression showed that participants who experienced flu-like symptoms, those in the healthcare sector, and those with higher adherence scores had higher odds for vaccine acceptability while being a female reduced the willingness to be vaccinated. In conclusion, our data suggest that the decreasing adherence to COVID-19 preventive measures may have caused increased flu-like symptoms over time. COVID-19 vaccine acceptance in Somalia is relatively high but could be improved by addressing factors that contribute to vaccine hesitancy.

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“…For instance, recently an Iranian cleric urged public not to get COVID-19 vaccine as it could possibly make people homosexual [9]. Similarly, in Malaysia and Indonesia, public raised a great hue and cry against COVID-19 vaccination drive based on a piece of misinformation that "the vaccine is Haram as it contains pork gelatin" [10] . In line with this, Islamic clerics in UAE and India passed a religious decree against COVID-19 vaccine that adversely affected the uptake of the vaccine in the Muslim communities.…”

Section: Vaccine Hesitancy Based On Misinformation Disinformation and Conspiracy Theoriesmentioning

confidence: 99%

The Perils of Vaccine Hesitancy Based on Conspiracy Theories and Misinformation: Implications and Way Forward for Pakistan

Mubarak

Khan

Tariq

et al. 2021

JUMDC

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BACKGROUND:Around the world, COVID-19 pandemic has exposed vulnerabilities of healthcare systems and whipped out years of progress on poverty alleviation. Nevertheless, the development of multiple COVID-19 vaccines in such a short span of time is truly a triumph of science. World Health Organization (WHO) grades vaccination as "one of the most cost-effective public health interventions to date" [1] . Vaccines work in two distinct ways i.e., directly protecting the one who receives and indirectly, as the vaccinated people could not infect others subsequently. In this way a vaccine reduces the number of hospital admissions and deaths. How swiftly would this combined effect appear at a population level is determined by the duration and the scale of vaccination efforts. To achieve a population level effect of COVID-19 vaccine in a country; different approaches to vaccinate masses are under huge discussion to decide the priority population i.e., who will receive the jab first. From a youth first approach as in Indonesia to textured approaches, as in Pakistan, that prioritize the vulnerable or exposed populations i.e., elderly and healthcare professionals respectively [2] .

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Unique product quality considerations in vaccine development, registration and new program implementation in Malaysia

Cited by 31 publications

References 25 publications

COVID-19 Vaccination Intent and Willingness to Pay in Bangladesh: A Cross-Sectional Study

COVID-19 Vaccination Intent and Willingness to Pay in Bangladesh: A Cross-Sectional Study

COVID-19 Vaccine Acceptability and Adherence to Preventive Measures in Somalia: Results of an Online Survey

The Perils of Vaccine Hesitancy Based on Conspiracy Theories and Misinformation: Implications and Way Forward for Pakistan

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