Unique Properties and Behavior of Nonmercerized Type-II Cellulose Nanocrystals as Carbon Nanotube Biocompatible Dispersants

González‐Domínguez, José M.; Ansón‐Casaos, Alejandro; Grasa, Laura; Abenia, Luis; Salvador-Porroche, Alba; Colom, Eduardo; Mesonero, José E.; García-Bordejé, José Enrique; Benito, Ana M.; Maser, Wolfgang K.

doi:10.1021/acs.biomac.9b00722

Cited by 33 publications

(68 citation statements)

References 49 publications

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“…Cancer cells can be killed by nanocellulose-CNT dispersions even without the presence of anticancer drugs. For example, nonmercerized type-II cellulose nanocrystals in dispersions with SWCNTs displayed cytotoxicity for human epithelial colorectal adenocarcinoma Caco-2 cells, but they enhanced the mitochondrial metabolism of normal cells [149].…”

Section: Biomedical Application Of Nanocellulose/cnt Compositesmentioning

confidence: 99%

“…The vast majority of studies dealing with potential biomedical applications of nanocellulose/nanocarbon composites have reported no cytotoxicity or negligible cytotoxicity of these composites, namely of nanocellulose/fullerene composites [35], nanocellulose/graphene composites [68,69,72,87,107], nanocellulose/CNT composites [51,149] and nanocellulose/nanodiamond composites [58,62,97]. Composites containing other carbon nanoparticles, such as activated carbon nanoparticles [30] or carbon quantum dots [28] have also shown no significant cytotoxic effects.…”

Section: Potential Cytotoxicity and Immunogenicity Of Nanocellulose/nmentioning

confidence: 99%

“…CNCs and their cationic derivatives CNC-aminoethylmethacrylate and CNC-aminoethylmethacrylamide evoked an inflammatory response in mouse macrophage J774A.1 cells and in peripheral blood mononuclear cells by increasing the level of ROS in mitochondria, the release of ATP from mitochondria and by stimulating the secretion of interleukin-1beta (IL-1β) [171]. The cytotoxicity and immunogenicity of CNCs depend on the preparation conditions and are increased under harsh and caustic conditions, e.g., the so-called mercerization process, i.e., an alkali treatment [149]. CNFs can also cause cytotoxicity and oxidative damage, which can be even more pronounced than in the case of CNCs, and can evoke an inflammatory response (for a review, see [2,172]).…”

Section: Potential Cytotoxicity and Immunogenicity Of Nanocellulose/nmentioning

confidence: 99%

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Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine

et al. 2020

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Nanocellulose/nanocarbon composites are newly emerging smart hybrid materials containing cellulose nanoparticles, such as nanofibrils and nanocrystals, and carbon nanoparticles, such as “classical” carbon allotropes (fullerenes, graphene, nanotubes and nanodiamonds), or other carbon nanostructures (carbon nanofibers, carbon quantum dots, activated carbon and carbon black). The nanocellulose component acts as a dispersing agent and homogeneously distributes the carbon nanoparticles in an aqueous environment. Nanocellulose/nanocarbon composites can be prepared with many advantageous properties, such as high mechanical strength, flexibility, stretchability, tunable thermal and electrical conductivity, tunable optical transparency, photodynamic and photothermal activity, nanoporous character and high adsorption capacity. They are therefore promising for a wide range of industrial applications, such as energy generation, storage and conversion, water purification, food packaging, construction of fire retardants and shape memory devices. They also hold great promise for biomedical applications, such as radical scavenging, photodynamic and photothermal therapy of tumors and microbial infections, drug delivery, biosensorics, isolation of various biomolecules, electrical stimulation of damaged tissues (e.g., cardiac, neural), neural and bone tissue engineering, engineering of blood vessels and advanced wound dressing, e.g., with antimicrobial and antitumor activity. However, the potential cytotoxicity and immunogenicity of the composites and their components must also be taken into account.

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Section: Biomedical Application Of Nanocellulose/cnt Compositesmentioning

confidence: 99%

Section: Potential Cytotoxicity and Immunogenicity Of Nanocellulose/nmentioning

confidence: 99%

Section: Potential Cytotoxicity and Immunogenicity Of Nanocellulose/nmentioning

confidence: 99%

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Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine

et al. 2020

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“…Due to its intrinsic chemical nature and the sustainability of the source material, nanocellulose may be considered an environmentally friendly nanomaterial. Despite the scarcity of scientific studies, there are already some examples showing the enormous potential that nanocellulose has as an aqueous dispersing agent of reduced GO and carbon nanotubes [21,22]. The structural diversity of NCC is defined by its crystalline allomorphs, among which types I and II stand out [22].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the scarcity of scientific studies, there are already some examples showing the enormous potential that nanocellulose has as an aqueous dispersing agent of reduced GO and carbon nanotubes [21,22]. The structural diversity of NCC is defined by its crystalline allomorphs, among which types I and II stand out [22]. While type I NCC (exhibiting cellulose chains parallel to each other) is dominant in nature, type II is artificially synthesized, presenting polymer chains in antiparallel arrangements and typically requiring extreme caustic conditions or recrystallization processes for its synthesis.…”

Section: Introductionmentioning

confidence: 99%

Waterborne Graphene- and Nanocellulose-Based Inks for Functional Conductive Films and 3D Structures

et al. 2021

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In the vast field of conductive inks, graphene-based nanomaterials, including chemical derivatives such as graphene oxide as well as carbon nanotubes, offer important advantages as per their excellent physical properties. However, inks filled with carbon nanostructures are usually based on toxic and contaminating organic solvents or surfactants, posing serious health and environmental risks. Water is the most desirable medium for any envisioned application, thus, in this context, nanocellulose, an emerging nanomaterial, enables the dispersion of carbon nanomaterials in aqueous media within a sustainable and environmentally friendly scenario. In this work, we present the development of water-based inks made of a ternary system (graphene oxide, carbon nanotubes and nanocellulose) employing an autoclave method. Upon controlling the experimental variables, low-viscosity inks, high-viscosity pastes or self-standing hydrogels can be obtained in a tailored way. The resulting inks and pastes are further processed by spray- or rod-coating technologies into conductive films, and the hydrogels can be turned into aerogels by freeze-drying. The film properties, with respect to electrical surface resistance, surface morphology and robustness, present favorable opportunities as metal-free conductive layers in liquid-phase processed electronic device structures.

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Metal‐free nanostructured‐carbon inks for a sustainable fabrication of zinc/air batteries: From ORR activity to a simple prototype

et al. 2023

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Zinc/air batteries are convenient energy storage devices for both small and massive applications. While future perspectives indicate the need for low‐cost components and sustainable fabrication processes, the battery performance is in part controlled by the kinetics of the oxygen reduction reaction (ORR), which typically involves transition metals as catalysts. In this context, we prepare a series of metal‐free water‐based carbon inks, which are tested for their catalytic performance, once being deposited on a gas‐diffusion substrate, in the air cathode of a simple battery prototype. The inks contain a variety of well‐defined carbon nanomaterials and additives, exhibiting different physicochemical properties that critically influence the interaction with the gas diffusion hydrophobic substrate. The intrinsic ORR catalytic activity of the ink material is also analysed on a glassy carbon electrode by the rotating ring‐disc electrode (RRDE) method and specific capacitance measurements. The discharge capacity on our zinc/air battery prototype well correlates with the intrinsic catalytic activity in the RRDE. However, only the activity in the RRDE does not actually assure the performance on the commercial cathode of the prototype, since other chemical compatibility issues play a role. Thus, we highlight the importance of catalyst testing, not only on the RRDE, but also under realistic device conditions.This article is protected by copyright. All rights reserved.

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Unique Properties and Behavior of Nonmercerized Type-II Cellulose Nanocrystals as Carbon Nanotube Biocompatible Dispersants

Cited by 33 publications

References 49 publications

Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine

Applications of Nanocellulose/Nanocarbon Composites: Focus on Biotechnology and Medicine

Waterborne Graphene- and Nanocellulose-Based Inks for Functional Conductive Films and 3D Structures

Metal‐free nanostructured‐carbon inks for a sustainable fabrication of zinc/air batteries: From ORR activity to a simple prototype

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