Unique Syndromes Involving the Skin Induced by Drugs, Food Additives, and Environmental Contaminants

Fixed drug reaction may be sexually induced

“…The authors excluded idiopathic eruptive macular pigmentation. They quoted previous reports, 2,3 documenting a significant minority of patients with FDE or FDLE with no significant drug history but persisting to exhibit such eruptions. These situations are frustrating to the patients as well as their physicians.…”

Fixed drug eruption and fixed drug‐like eruption

“…A dermatologist in another part of the country had documented the following: “The most curious aspect of FDE in this clinic (in Lagos) was the fact that eruptions continue to occur despite the patients’ assertion that they had abstained from all drugs except those prescribed in this clinic.” 2 Although not documented in relationship to FDE, nonmedicinal products as an overlooked group causing dermatoses has been appreciated for approximately three decades 3 . These substances referred to as “borderline substances” 4 include biocides (herbicides, insecticides), and additives to food (colorings, preservatives and emulsifiers).…”

Pseudolymphoma Syndrome

“…The clinical picture of pseudolymphoma consists of generalized lymphadenopathy, malaise, fever and a skin rash, with the frequent association of pain and swelling in the joints as well as hepatosplenomegaly [1,2,[5][6][7][8][9]. In some cases diarrhea may be a part of this picture [10,11].…”