Unique therapeutic potentialities of exosomes based nanodrug carriers to target tumor microenvironment in cancer therapy

Khan, Safir Ullah; Khan, Munir Ullah; Gao, Y.; Khan, Muhammad Imran; Puswal, Sabah Mushtaq; Zubair, Muhammad; Khan, Muhammad Asif; Farwa, Rahat; Gao, Shuang; Ali, Rizwan; Bilal, Muhammad

doi:10.1016/j.onano.2022.100091

Cited by 14 publications

(1 citation statement)

References 162 publications

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“…Effective safeguarding and precise delivery of biofunctional enzymes or drug molecules are pivotal for the intervention and therapy of various diseases. − Consequently, the advancement of molecular delivery strategies and platforms contributes to the conversion of potential solutions into successful therapeutic methodologies. Among the diverse delivery systems, exosome-biomimetic nanoplatforms offer a highly favorable choice. − Exosomes, which are 30–150 nm sized extracellular vesicles secreted by various kinds of cells, play a paramount role in cell-to-cell communications by facilitating the transfer of proteins, nucleic acids, and lipids. − The stable lipid bilayer membrane structure coupled with similar composition as cells enables exosomes low immunogenicity, prolonged circulation, and phagocytosis prevention, , thereby endowing them with the ability to protect internal molecules. Notably, the “homing” effect of exosomes confers them with the targeting capability, aiding in the accumulation of internal substances at specific sites .…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Exosome-Sheathed Magnetic Mesoporous Anchor with Modification of Glucose Oxidase for Synergistic Targeting and Starving Tumor Cells

Li,

Tai,

Shen

et al. 2024

ACS Appl. Mater. Interfaces

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Efficient protection and precise delivery of biomolecules are of critical importance in the intervention and therapy of various diseases. Although diverse specific marker-functionalized drug carriers have been developed rapidly, current approaches still encounter substantial challenges, including strong immunogenicity, limited target availability, and potential side effects. Herein, we developed a biomimetic exosome-sheathed magnetic mesoporous anchor modified with glucose oxidase (MNPs@mSiO2-GOx@EM) to address these challenges and achieve synergistic targeting and starving of tumor cells. The MNPs@mSiO2-GOx@EM anchor integrated the unique characteristics of different components. An external decoration of exosome membrane (EM) with high biocompatibility contributed to increased phagocytosis prevention, prolonged circulation, and enhanced recognition and cellular uptake of loaded particles. An internal coated magnetic mesoporous core with rapid responsiveness by the magnetic field guidance and large surface area facilitated the enrichment of nanoparticles at the specific site and provided enough space for modification of glucose oxidase (GOx). The inclusion of GOx in the middle layer accelerated the energy-depletion process within cells, ultimately leading to the starvation and death of target cells with minimal side effects. With these merits, in vitro study manifested that our nanoplatform not only demonstrated an excellent targeting capability of 94.37% ± 1.3% toward homotypic cells but also revealed a remarkably high catalytical ability and cytotoxicity on tumor cells. Assisted by the magnetic guidance, the utilization of our anchor obviously inhibits the tumor growth in vivo. Together, our study is promising to serve as a versatile method for the highly efficient delivery of various target biomolecules to intended locations due to the fungibility of exosome membranes and provide a potential route for the recognition and starvation of tumor cells.

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Section: Introductionmentioning

confidence: 99%

Biomimetic Exosome-Sheathed Magnetic Mesoporous Anchor with Modification of Glucose Oxidase for Synergistic Targeting and Starving Tumor Cells

Li,

Tai,

Shen

et al. 2024

ACS Appl. Mater. Interfaces

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Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Papakonstantinou,

Roumeliotou,

Pantazaka

et al. 2024

Molecular Oncology

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The increased metastatic ability of small‐cell lung cancer (SCLC) necessitates the identification of new prognostic biomarkers for clinical evaluation during the disease course. Our previous research highlighted the clinical relevance of transcription factor JunB (JUNB), C‐X‐C chemokine receptor type 4 (CXCR4), and programmed cell death 1 ligand 1 (PD‐L1) in breast and non‐small cell lung cancer (NSCLC) patients. In the current study, we examined these biomarkers in circulating tumor cells (CTCs) and plasma‐derived exosomes from 100 treatment‐naïve SCLC patients. CTCs were analyzed using the VyCAP system, whereas exosomes were characterized molecularly and transcriptomically. JUNB, CXCR4, and PD‐L1 were highly prevalent in CTCs. Patients exhibited significantly increased protein exosomal expression of JUNB and CXCR4 compared to healthy individuals. Overexpression of JUNB and CXCR4 in exosomes can distinguish patients from normal donors, offering an interesting tool for early diagnosis. The presence of JUNB and/or CXCR4 in CTCs correlated with significantly poorer overall survival. CXCR4 exosomal overexpression was associated with CTC presence and their phenotypes. Conclusively, a comprehensive analysis of CTCs and exosomes provides useful prognostic and potential diagnostic tools for SCLC patients.

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Beyond the silence: A comprehensive exploration of long non-coding RNAs as genetic whispers and their essential regulatory functions in cardiovascular disorders

Xiong,

Alnoud,

Ali

et al. 2024

Current Problems in Cardiology

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Unique therapeutic potentialities of exosomes based nanodrug carriers to target tumor microenvironment in cancer therapy

Cited by 14 publications

References 162 publications

Biomimetic Exosome-Sheathed Magnetic Mesoporous Anchor with Modification of Glucose Oxidase for Synergistic Targeting and Starving Tumor Cells

Biomimetic Exosome-Sheathed Magnetic Mesoporous Anchor with Modification of Glucose Oxidase for Synergistic Targeting and Starving Tumor Cells

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Beyond the silence: A comprehensive exploration of long non-coding RNAs as genetic whispers and their essential regulatory functions in cardiovascular disorders

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