We show the existence of isoperimetric regions of sufficiently large volumes in general asymptotically hyperbolic three manifolds. Furthermore, we show that large coordinate spheres in compact perturbations of Schwarzschild-anti-deSitter are uniquely isoperimetric. This is relevant in the context of the asymptotically hyperbolic Penrose inequality.Our results require that the scalar curvature of the metric satisfies Rg ≥ −6, and we construct an example of a compact perturbation of Schwarzschild-anti-deSitter without Rg ≥ −6 so that large centered coordinate spheres are not isoperimetric. The necessity of scalar curvature bounds is in contrast with the analogous uniqueness result proven by Bray for compact perturbations of Schwarzschild, where no such scalar curvature assumption is required.This demonstrates that from the point of view of the isoperimetric problem, mass behaves quite differently in the asymptotically hyperbolic setting compared to the asymptotically flat setting. In particular, in the asymptotically hyperbolic setting, there is an additional quantity, the "renormalized volume," which has a strong effect on the large-scale geometry of volume.I am very grateful to my advisor, Simon Brendle, for suggesting this problem, as well as for his invaluable assistance, support, and many suggestions on a preliminary version of this paper. Additionally, I would like to thank Michael Eichmair and Brian White for patiently answering numerous questions, as well as for their continued encouragement. Finally, I would like to acknowledge