United Arab Emirates: Unusual departure from neutrality towards excess of homozygotes at the HLA‐B locus

Al‐Yafei, Zain; Goeury, Thomas; Alvares, Marion; Seiari, M. Al; Sanchez‐Mazas, Alicia; ElGhazali, Gehad

doi:10.1111/tan.13774

Cited by 1 publication

(3 citation statements)

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“…The apparent discrepancies between our results and those of other populations can be attributed to several factors, including race/ethnicity, incidence of T1D, sample size, genotyping methods, and other factors ( Park, 2007 ; Polychronakos and Li 2011 ). This was highlighted by the HLA allele/haplotype frequencies between our population and Europeans, Africans, and East Asians ( Al-Yafei et al, 2019 ; Arnaiz-Villena et al, 2019 ). This in turn explains, at least in part, the variations in T1D prevalence and incidence ( Patterson et al, 2012 ).…”

Section: Discussionmentioning

confidence: 53%

“…DQB1*03:03 , DRB1*08:01 , DRB1*08:02, and DRB1*09:01 were rare among patients or controls in the present study. Moreover, DRB1*03:02 was rare in the Emirati study population ( Al-Yafei et al, 2019 ; Arnaiz-Villena et al, 2019 ) and European derived populations; and frequent in DQB1*04:02 -containing haplotypes in Africans, protecting against T1D ( Howson et al, 2013 ). DQB1*04:01 , common in East Asians ( Kawabata et al, 2002 ), is rare in Emiratis ( Al-Yafei et al, 2019 ; Arnaiz-Villena et al, 2019 ).…”

Section: Discussionmentioning

confidence: 90%

“…Moreover, DRB1*03:02 was rare in the Emirati study population ( Al-Yafei et al, 2019 ; Arnaiz-Villena et al, 2019 ) and European derived populations; and frequent in DQB1*04:02 -containing haplotypes in Africans, protecting against T1D ( Howson et al, 2013 ). DQB1*04:01 , common in East Asians ( Kawabata et al, 2002 ), is rare in Emiratis ( Al-Yafei et al, 2019 ; Arnaiz-Villena et al, 2019 ). Furthermore, several DRB1∼DQB1 haplotypes associated with T1D in Europeans, Asians, and Africans were not observed here.…”

Section: Discussionmentioning

confidence: 90%

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HLA-DRB1 and –DQB1 Alleles, Haplotypes and Genotypes in Emirati Patients with Type 1 Diabetes Underscores the Benefits of Evaluating Understudied Populations

et al. 2022

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Background: HLA class II (DR and DQ) alleles and antigens have historically shown strong genetic predisposition to type 1 diabetes (T1D). This study evaluated the association of DRB1 and DQB1 alleles, genotypes, and haplotypes with T1D in United Arab Emirates.Materials and Methods: Study subjects comprised 149 patients with T1D, and 147 normoglycemic control subjects. Cases and controls were Emiratis and were HLA-DRB1 and -DQB1 genotyped using sequence-based typing. Statistical analysis was performed using Bridging Immunogenomic Data-Analysis Workflow Gaps R package.Results: In total, 15 DRB1 and 9 DQB1 alleles were identified in the study subjects, of which the association of DRB1*03:01, DRB1*04:02, DRB1*11:01, DRB1*16:02, and DQB1*02:01, DQB1*03:02, DQB1*03:01, and DQB1*06:01 with altered risk of T1D persisted after correcting for multiple comparisons. Two-locus haplotype analysis identified DRB1*03:01∼DQB1*02:01 [0.44 vs. 0.18, OR (95% CI) = 3.44 (2.33–5.1), Pc = 3.48 × 10−10]; DRB1*04:02∼DQB1*03:02 [0.077 vs. 0.014, OR = 6.06 (2.03–24.37), Pc = 2.3 × 10−3] and DRB1*04:05∼DQB1*03:02 [0.060 vs. 0.010, OR = 6.24 (1.79–33.34), Pc = 0.011] as positively associated, and DRB1*16:02∼DQB1*05:02 [0.024 vs. 0.075, OR = 0.3 (0.11–0.74), Pc = 0.041] as negatively associated with T1D, after applying Bonferroni correction. Furthermore, the highest T1D risk was observed for DR3/DR4 [0.104 vs. 0.006, OR = 25.03 (8.23–97.2), Pc = 2.6 × 10−10], followed by DR3/DR3 [0.094 vs. 0.010, OR = 8.72 (3.17–25.32), Pc = 3.18 × 10−8] diplotypes.Conclusion: While DRB1 and DQB1 alleles and haplotypes associated with T1D in Emiratis showed similarities to Caucasian and non-Caucasian populations, several alleles and haplotypes associated with T1D in European, African, and Asian populations, were not observed. This underscores the contribution of ethnic diversity and possible diverse associations between DRB1 and DQB1 and T1D across different populations.

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