United in Prevention-Electrocardiographic Screening for Chronic Obstructive Pulmonary Disease

Lazović, Biljana; Mazić, Sanja; Stajic, Zoran; Djelić, Marina; Zlatković-Švenda, Mirjana; Putniković, Biljana

doi:10.5455/aim.2013.21.127-128

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Due to the strong association between cardiovascular disease and COPD, ECG screening is a fast, easy, and readily available option, as anomalies in P-waves are associated with both cardiovascular and pulmonary disease. 21 Abnormal P-wave axis, even when adjusted for age, sex, and morbidity, is associated with increased risk of death. 22 Abnormal cardiac repolarization, a risk factor for sudden cardiac death, has been found to be prevalent in one-third of COPD patients.…”

Section: Discussionmentioning

confidence: 99%

Czech multicenter research database of severe COPD

Novotná¹,

Koblížek²,

Zatloukal³

et al. 2014

COPD

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PurposeChronic obstructive pulmonary disease (COPD) has been recognized as a heterogeneous, multiple organ system-affecting disorder. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) places emphasis on symptom and exacerbation management. The aim of this study is examine the course of COPD and its impact on morbidity and all-cause mortality of patients, with respect to individual phenotypes and GOLD categories. This study will also evaluate COPD real-life patient care in the Czech Republic.Patients and methodsThe Czech Multicentre Research Database of COPD is projected to last for 5 years, with the aim of enrolling 1,000 patients. This is a multicenter, observational, and prospective study of patients with severe COPD (post-bronchodilator forced expiratory volume in 1 second ≤60%). Every consecutive patient, who fulfils the inclusion criteria, is asked to participate in the study. Patient recruitment is done on the basis of signed informed consent. The study was approved by the Multicentre Ethical Committee in Brno, Czech Republic.ResultsThe objective of this paper was to outline the methodology of this study.ConclusionThe establishment of the database is a useful step in improving care for COPD subjects. Additionally, it will serve as a source of data elucidating the natural course of COPD, comorbidities, and overall impact on the patients. Moreover, it will provide information on the diverse course of the COPD syndrome in the Czech Republic.

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Section: Discussionmentioning

confidence: 99%

Czech multicenter research database of severe COPD

Novotná¹,

Koblížek²,

Zatloukal³

et al. 2014

COPD

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“…A series of studies suggest COPD is associated with a disturbance of autonomic function manifested by increased sympathetic activation [ 112 – 115 ] and loss of normal circadian variations in heart rate [ 116 ]. Finally, vertical P wave axis correlates with a diagnosis of COPD, as measured by P wave amplitude in lead III > lead I and/or a dominantly negative P wave in lead aVL, findings that indicate a P wave axis >60° [ 117 – 119 ]. As such, vertical P wave axis on ECG has been suggested as a screening tool for unrecognized COPD.…”

Section: Markers Of Cardiac Disease In Aecopdmentioning

confidence: 99%

Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Cardiovascular Links

Laratta

Eeden

2014

BioMed Research International

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Chronic obstructive pulmonary disease (COPD) is a chronic, progressive lung disease resulting from exposure to cigarette smoke, noxious gases, particulate matter, and air pollutants. COPD is exacerbated by acute inflammatory insults such as lung infections (viral and bacterial) and air pollutants which further accelerate the steady decline in lung function. The chronic inflammatory process in the lung contributes to the extrapulmonary manifestations of COPD which are predominantly cardiovascular in nature. Here we review the significant burden of cardiovascular disease in COPD and discuss the clinical and pathological links between acute exacerbations of COPD and cardiovascular disease.

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“…COPD is often associated with cardiovascular diseases, thus representing one of the most frequent and clinically important coexisting condition. An accumulating body of evidence indicates COPD association with coronary artery disease (CAD), chronic heart failure (CHF), hypertension and cardiac arrhythmias, independent of shared risk factors [6,7]. Apart from the common risk factors presence (age, smoking habit, environmental pollutants, gender and diet), it appears that multiple pathophysiologic abnormalities contribute to both the COPD and CAD development and progression.…”

Section: Introductionmentioning

confidence: 99%

“…Apart from the common risk factors presence (age, smoking habit, environmental pollutants, gender and diet), it appears that multiple pathophysiologic abnormalities contribute to both the COPD and CAD development and progression. COPD and CAD association is characterized by specific electrocardiographic (ECG) abnormalities [5,6,7].…”

Section: Introductionmentioning

confidence: 99%

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Electrocardiographic predictors of five-years mortality in chronic obstructive pulmonary disease patients

et al. 2021

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Introduction/Objective. Cardiovascular disease is one of the most common comorbidities among subjects with chronic obstructive pulmonary disease (COPD). The aim of this study is to evaluate ECG parameters and mortality predictors in COPD patients. Methods. A total of 835 consecutive patients were included. Patients were classified to suffer from COPD if in three consecutive postbronhodilatator measurements FEV1/FVC was <70%. Following ECG changes were observed: axis, p wave, low ORS complex, transitional zone, left bundle branch block (LBBB), right bundle branch block (RBBB), incomplete right bundle branch block, S1S2S3 configuration, negative T in V1-V3. Patients were followed up for mortality in a five years period. Results. Both survivors and non-survivors were similar age, gender and COPD status. FVC and FEV1 as well as GOLD stadium are significantly higher in surviving group (p<0.016, p<0.001, p<0.001 respectively). Normal axis was in significantly higher percentage in non-survived patients (p=0.020). Right RBBB and incomplete RBB are more frequent finding in patients who died as (p?0.001, p?0.05, respectively). LBBB, S1S2S3 configuration is in significantly higher percent in non survivors (p<0.016, p<0.001, respectively). In multivariable logistic model, patients with LBBB have two times higher chance of mortality compared to patients without LBBB. Contrary, patients with RBBB have 1.6 times lower chance to have death outcome. Conclusion. Main ECG predictors of COPD patients? five-year mortality are LBBB and RBBB, but according to statistical model, electrocardiogram should be further explored and possibly obligatory involved in a routine clinical practice as an easy and low-cost screening method.

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United in Prevention-Electrocardiographic Screening for Chronic Obstructive Pulmonary Disease

Cited by 6 publications

References 6 publications

Czech multicenter research database of severe COPD

Czech multicenter research database of severe COPD

Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Cardiovascular Links

Electrocardiographic predictors of five-years mortality in chronic obstructive pulmonary disease patients

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