Background
Persons with inflammatory bowel disease (IBD) have an increased risk of venous thromboembolism (VTE). We sought to examine whether self-report of hormonal contraception (HC), as a proxy for exposure to estrogen-based contraception, was less common for women with multiple risk factors for VTE.
Methods
We examined the prevalence of personal use of hormonal birth control in a large internet-based cohort of patients with IBD. To determine whether HC was less common among IBD patients with increased risk of thrombosis, we estimated unadjusted and adjusted prevalence ratios (PR and aPR) for use of HC.
Results
1,499 female survey respondents answered optional fertility questions and were included in the analysis. The prevalence of HC was 33.7% (95% CI 30.6 – 36.9%) among women with Crohn’s disease and was 32.6% (95% CI 28.6 – 36.8%) for women with ulcerative colitis. Women with one risk factor for thrombosis were not significantly less likely to receive hormonal contraception (PR = 0.91, 95% CI 0.76 – 1.08; aPR = 0.94, 95% CI 0.80 – 1.11) compared to women without risk factors, nor were women with two or more risk factors (PR = 1.10, 95% CI 0.56 – 1.28; aPR = 1.10, 95% CI 0.83 – 1.45). Use of an intrauterine device was also similar between women with and without risk factors for VTE.
Conclusion
The prevalence of HC use in women with multiple risk factors was similar to that in women without risk factors, which represents an opportunity for prevention. Gastroenterologists should ask IBD patients using HC about risk factors for thromboembolic disease to identify patients who may benefit from alternative contraception.