United States Multicenter Study of Arsenic Trioxide in Relapsed Acute Promyelocytic Leukemia

Abstract

This study establishes ATO as a highly effective therapy for patients with relapsed APL.

How to manage acute promyelocytic leukemia

“…With subsequent ATO treatment or HSCT, the 18-month OS and relapse-free survival were 66% and 56%, respectively. 81 Alimoghaddam et al 87 have also conducted similar research in which 31 patients who relapsed from ATRA plus chemotherapy were reinduced to remission and consolidated by a single agent of ATO. After a median time of 32 months of follow-up, it was found that 10 (41.6%) patients relapsed in the 24 CR2 patients.…”

p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription

“…They have also been utilized clinically to treat various human diseases including psoriasis, syphilis, and rheumatosis. Recent clinical use of trivalent arsenic as an anticancer drug, especially in the treatment of acute promyelocytic leukemia [1][2][3], has stimulated intense interest in elucidating the underlying mechanisms of arsenicinduced apoptosis.…”

Antimony-trioxide- and arsenic-trioxide-induced apoptosis in myelogenic and lymphatic cell lines, recruitment of caspases, and loss of mitochondrial membrane potential are enhanced by modulators of the cellular glutathione redox system

“…We were interested in magnifying the efficacy of As 2 O 3 using substances that might be transferable to clinical application because the clinical applications of As 2 O 3 gain in importance not only for therapy of relapsed and refractory APL [29,30,[33][34][35][36][37][38][39][40][41][42][43][44][45][46][47], but also for treatment of multiple myeloma [48][49][50], myelodysplastic syndromes [51][52][53], and renal cancer [54]. Recently, two reports described apoptosis induction, caspase activation and ROS production by very high concentrations (up to 40 µM) of potassium antimonyl tartrate in lymphoid tumor cell lines [55] and growth inhibition and induction of apoptosis and reactive oxygen species [56].…”