Background: The role of the oncology nurse has evolved since the COVID-19 pandemic to continuously meet patient needs, resulting in an increased virtual presence. However, there is little information about whether these roles have continued since the pandemic and how it is affecting nurses. Methods: The aim of this study, conducted via an electronic survey questionnaire, was to examine the perspective of oncology nurses in the United States of America regarding how their role has changed, the adaptation to telehealth, challenges, and needs. Results: Over 5 months, 197 respondents from 17 different states completed the survey. They were all registered nurses working in oncology with different roles, such as being nurse practitioners (23%), nurse navigators (20%), infusion nurses (23%), and working in outpatient settings (93%). The findings of the survey highlight the multifaceted responsibilities of nurses in providing care across the cancer care continuum, emphasizing patient-centered care, communication, education, and empowerment, in addition to expected duties such as the administration of anticancer therapy, monitoring of side effects, and symptom management. A total of 82.6% of United States of America oncology nurses feel their workload has increased. The role of nurses in oncology is continuously evolving and the impact of the COVID-19 pandemic, in certain areas such as telehealth, is here to stay. Conclusions: The results of the study allow a better understanding of the emergent roles of oncology nursing. The importance of self-care initiatives and education are emphasized as critical to support nurses in their complex, busy, and emotionally charged work environment and to help retain existing nurses and attract new individuals into the profession. The study ultimately seeks to inform policy and drive professional development in oncology nursing in the United States of America.