Univariate and multivariate assisted spectrophotometric methods for determination of rosuvastatin calcium and fenofibrate in bulk powders and tablets along with their degradation products

Hegazy, Maha A.; Bakr, Maryam A.; Badawey, Amr M.; Abbas, Samah S.

doi:10.1016/j.saa.2020.119163

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…2021 -European Journal of Chemistry -CC BY NC -DOI: 10.5155/eurjchem.12.4.368-376.2144 For both PLS-2 and PCR, the concentration residuals were plotted against the actual concentrations of the prepared mixtures (Figures 7 and 8), and the residuals for all samples were found to be randomly distributed around zero [25][26][27][28][29][30][31][32][33]. The average recoveries of each drug using PLS-2 and PCR methods are summarized in Table 2.…”

Section: Multivariate Chemometric Methods: (Pls-2) and (Pcr)mentioning

confidence: 99%

“…The validation set is composed of 5 laboratory-prepared mixtures containing different proportions of AMP, SQX, and DVD (Table 1). In addition, the concentrations of AMP, SQX, and DVD in the veterinary formulation extract were calculated using the optimized PLS-2 or PCR calibration model after being recorded in the same specified lambda range [25][26][27][28][29][30][31][32][33].…”

Section: Pls-2 and Pcrmentioning

confidence: 99%

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Universal procedures for spectrophotometric determination of anticoccidial drugs; application to multi-ingredient veterinary formulation and computational investigations for multivariate analysis

et al. 2021

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Simple, accurate, and eco-friendly spectrophotometric procedures were proposed and implemented for simultaneous determination of anticoccidial drugs from three different classes namely, amprolium hydrochloride (AMP), sulfaquinoxaline sodium (SQX) and diaveridine hydrochloride (DVD). Dual wavelength in ratio spectra procedure was proposed where the difference in amplitudes (ΔP) in the ratio spectra at 264 nm and 301.9 nm (ΔP264&301.9 nm) corresponded to AMP with mean percentage recovery 100.00±0.923%, while (ΔP250.9&279 nm) and (ΔP218&243.5 nm) corresponded to SQX and DVD with mean percentage recoveries 99.31±1.083 and 100.64±1.219%, respectively. The dual wavelength in ratio spectra procedure was validated according to the ICH guidelines and accuracy, precision and repeatability were found to be within the acceptable limit. Multivariate chemometric approaches, namely, partial least-squares (PLS-2) and principal component regression (PCR) were also proposed with mean percentage recoveries 99.31±0.769, 98.91±1.192 and 99.04±1.245% for AMP, SQX and DVD, respectively, in PLS-2 and 99.63±1.005, 99.11±1.272 and 98.93±1.338% for AMP, SQX and DVD, respectively, in PCR. These procedures were successfully applied to the multi-ingredient veterinary formulation with mean percentage recoveries 100.75±1.238, 99.29±0.875 and 99.34±0.745% for AMP, SQX and DVD, respectively, in dual wavelength in ratio spectra procedure and 101.03±1.261, 101.48±0.984 and 101.10±1.339% for AMP, SQX and DVD, respectively, in PLS-2 and 100.22±1.204, 101.10±0.546 and 100.91±0.677% for AMP, SQX and DVD, respectively, in PCR.

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Section: Multivariate Chemometric Methods: (Pls-2) and (Pcr)mentioning

confidence: 99%

Section: Pls-2 and Pcrmentioning

confidence: 99%

Universal procedures for spectrophotometric determination of anticoccidial drugs; application to multi-ingredient veterinary formulation and computational investigations for multivariate analysis

et al. 2021

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“…This is due to the fact that some side components may greatly affect the safety and effectiveness of drugs. High-performance (HP) liquid chromatography (LC) with UV detection [ 1 , 2 ], reversed-phase HPLC with photodiode array [ 3 , 4 , 5 ], UV [ 6 , 7 ] or fluorescence [ 7 ] detectors, HP thin-layer chromatography with densitometry [ 1 , 2 , 4 ], capillary zone electrophoresis [ 8 , 9 , 10 ], and spectrophotometry combined with chemometrics [ 11 , 12 , 13 , 14 , 15 , 16 ] can be used to control the degradation and purity of drugs. At the same time, there are two main approaches to the analysis.…”

Section: Introductionmentioning

confidence: 99%

“…In the first case, active ingredients are determined in the presence of side components so that the content of the latter does not influence an analytical signal [ 1 , 2 , 3 , 8 , 11 , 12 ]. The second approach is the simultaneous determination of drug components, including related organic impurities and degradation products [ 4 , 5 , 6 , 7 , 9 , 10 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Potentiometric Sensor Arrays Based on Hybrid PFSA/CNTs Membranes for the Analysis of UV-Degraded Drugs

et al. 2023

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The degradation of drugs is a substantial problem since it affects the safety and effectiveness of pharmaceutical products, as well as their influence on the environment. A novel system of three potentiometric cross-sensitive sensors (using the Donnan potential (DP) as an analytical signal) and a reference electrode was developed for the analysis of UV-degraded sulfacetamide drugs. The membranes for DP-sensors were prepared by a casting procedure from a dispersion of perfluorosulfonic acid (PFSA) polymer, containing carbon nanotubes (CNTs), whose surface was preliminarily modified with carboxyl, sulfonic acid, or (3-aminopropyl)trimethoxysilanol groups. A correlation between the sorption and transport properties of the hybrid membranes and cross-sensitivity of the DP-sensor to sulfacetamide, its degradation product, and inorganic ions was revealed. The analysis of the UV-degraded sulfacetamide drugs using the multisensory system based on hybrid membranes with optimized properties did not require a pre-separation of the components. The limits of detection of sulfacetamide, sulfanilamide, and sodium were 1.8 × 10−7, 5.8 × 10−7, and 1.8 × 10−7 M. The relative errors of the determination of the components of the UV-degraded sulfacetamide drugs were 2–3% (at 6–8% relative standard deviation). PFSA/CNT hybrid materials provided the stable work of the sensors for at least one year.

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Aliphatic substrates-mediated unique rapid room temperature synthesis of carbon quantum dots for fenofibrate versatile analysis

Abdel-Hakim,

Belal,

Hammad

et al. 2025

Analytica Chimica Acta

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Univariate and multivariate assisted spectrophotometric methods for determination of rosuvastatin calcium and fenofibrate in bulk powders and tablets along with their degradation products

Cited by 8 publications

References 22 publications

Universal procedures for spectrophotometric determination of anticoccidial drugs; application to multi-ingredient veterinary formulation and computational investigations for multivariate analysis

Universal procedures for spectrophotometric determination of anticoccidial drugs; application to multi-ingredient veterinary formulation and computational investigations for multivariate analysis

Potentiometric Sensor Arrays Based on Hybrid PFSA/CNTs Membranes for the Analysis of UV-Degraded Drugs

Aliphatic substrates-mediated unique rapid room temperature synthesis of carbon quantum dots for fenofibrate versatile analysis

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