The consequences of poverty, current technological innovation (the change of the nature of work) for the labour market and overall societal transformation strengthened the interest of governments, intergovernmental policy-making bodies and international experts in Article 25 of the Universal Declaration of Human Rights. This Declaration states that “Everyone has the right to a standard of living adequate for the health and well-being of himself and of his family, including food, clothing, housing and medical care and necessary social services, and the right to security in the event of unemployment, sickness, disability, widowhood, old age or other lack of livelihood in circumstances beyond his control”. The article alludes to a universal basic income/unconditional basic income (UBI)—a kind of cash welfare programme in which all citizens (or permanent residents) of a country receive a regular, liveable and unconditional amount of money from the government. Governments recommitted themselves to ensuring decent work and social protection for all through the 2030 Agenda for Sustainable Development. Article 25 has never been implemented globally through appropriate government interventions and redistributive measures. Such measures are and have been pursued on a trial basis as evidenced by country experiences contained in this chapter. This could eventually open the door to a global basic income elsewhere in the world, framed on the specific needs and conditions of countries. The United Nations Industrial Development Organization (UNIDO) likewise could explore whether such an unconditional income yields returns in terms of Inclusive Sustainable Industrial Development (ISID) within the framework of possible income and employment effects of UBI triggered by technical assistance and business support services. Such an endeavour would take UBI beyond its monetary threshold and make it a potential source of sustainable livelihoods for social wellbeing and income creation. In these unprecedented times, citizens in almost every country will face an uphill battle to address their socio-economic basic needs. The insecurity and great uncertainties caused by COVID-19 in 2020 and beyond, especially among the poor and small-scale businesses and subsistence farmers, will compel governments and UN agencies to develop new strategies. UBI, with all its variations, should be accepted as a universal condition and safety net for everyone.