The weak temperature dependence of the resistance R(T) of monolayer graphene 1-3 indicates an extraordinarily high intrinsic mobility of the charge carriers. Important complications are the presence of mobile scattering centres that strongly modify charge transport, and the presence of strong mesoscopic conductance fluctuations that, in graphene, persist to relatively high temperatures 4,5 . In this Letter, we investigate the surprisingly varied changes in resistance that we find in graphene flakes as temperature is lowered below 70 K. We propose that these changes in R(T) arise from the temperature dependence of the scattered electron wave interference that causes the resistance fluctuations. Using the field effect transistor configuration, we verify this explanation in detail from measurements of R(T) by tuning to different gate voltages corresponding to particular features of the resistance fluctuations. We propose simple expressions that model R(T) at both low and high charge carrier densities.Recently, several papers have presented systematic analyses of R(T) data in graphene [1][2][3] . Morozov et al.1 ascribed the strong increase of resistivity above a temperature of 200 K to scattering by flexural phonons 6 localized in ripples in the graphene sheet. Chen et al. 2 fitted their R(T) data to the usual linear term due to scattering by acoustic phonons and Bose-Einstein functions for scattering from specific high-energy phonons. They concluded that scattering by a pair of interfacial phonons in the SiO 2 substrate 7 was the most likely origin of the increase of R(T) at high temperatures, but also noted that their resistivity increase at high T was consistent with scattering by phonons of energy 104 meV. To eliminate the role of the substrate in limiting conductivity, Bolotin et al.3 investigated a suspended graphene flake, achieving near-ballistic transport with mobility ~120,000 cm 2 /Vs at 240 K. The resistivity increased linearly from 50 K to 240 K suggesting that longitudinal acoustic phonons were the main scatterers.For low charge carrier densities near the charge neutrality point (NP), the resistivity is less well understood, generally increasing as temperature decreases but sometimes showing a decrease below 150 K 1,8 . Cho and Fuhrer 9 and Chen et al. 10 concluded that the resistance of their graphene samples near the neutrality point (NP) was governed not by the physics of the Dirac singularity but by carrier-density inhomogeneities induced by the potential of charged impurities ("puddles" of electrons and holes as imaged by Martin et al. 11 ).We have measured the resistance of monolayer graphene samples as a function of temperature and gate voltage (see Methods section for details). Figure 1 shows a typical resistance at T = 4.2 K of a portion of graphene of length 1200 nm and width 1450 nm. The resistance as a function of gate voltage V G in Figure 1a shows the usual maximum in resistance (at the NP) with charge carrier density increasing for V G on either side of the maximum. The strong irregul...