Universal Detection of Mia Antigen and Frequencies of Glycophorin Hybrids among Blood Donors in Taiwan by Human Monoclonal Antibodies against Mia (MNS7), Mur (MNS10), and MUT (MNS35) Antigens

Yang, Meng Hua; Chen, Jen Wei; Kaito, Sayaka; Uchikawa, Makoto; Tsuno, Nelson H.; Wei, Sheng Tang; Hou, Sheng; Chen, Yann Jang

doi:10.3390/diagnostics11050806

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…From the perspective of population genetics, the concentration of a genotype in a historically isolated population (e.g., GYP.Mur in the Ami people) could be a consequence of the founder effect. However, this phenomenon is affected by increasing human migratory activities (e.g., urbanization and globalization), as demonstrated in Australia [33,39] and in the changing regional distribution of GP.Mur prevalence in Taiwan [2,38].…”

Section: Gpmur Blood Type As a Potential Inborn Physical Advantagementioning

confidence: 99%

“…We study the biology and physiology of the GP.Mur blood type in Taiwan. GP.Mur is a unique Southeast Asian phenotype (rare outside Southeast Asia), with 2-6% prevalence in different regions of Taiwan [1,2], but with significantly higher prevalence in several tribes and on some elite sport teams (e.g., track, baseball, and soccer). Intriguingly, the biological function of GP.Mur is to promote blood CO 2 respiration, which conceivably benefits exercise metabolism.…”

Section: Introductionmentioning

confidence: 99%

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What Decides Your Athletic Career?—Reflection from Our Study of GP.Mur-Associated Sports Talents during the COVID-19 Pandemic Era

Hsu

Tseng

2022

IJERPH

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This opinion article discusses the factors that attract children and teens to athletic careers. The most important attribute for the making of athletes is polished sports talent, followed by psychological, environmental, and incentive factors. Our laboratory studies a red blood cell (RBC) type called GP.Mur, which is rare in most parts of the world besides Southeast Asia. Intriguingly, the prevalence of the GP.Mur blood type is relatively high among Taiwanese elite athletes. The highest frequency of the GP.Mur blood type worldwide is found among Taiwan’s Ami people (88–95% from hospital blood bank surveys in the 1980s). Though the Ami constitute only 0.6–0.8% of the Taiwanese population, from records of national track-and-field games in the past century, 10–60% of the medalists were Ami. Biologically, GP.Mur expression supports blood CO2 metabolism, which may have implications for athleticism. As many of our study subjects are elite college athletes with the GP.Mur blood type, we contemplated their upbringings and career dilemmas, especially during the difficult COVID-19 pandemic. Beyond individual sports talent, the pandemic particularly tests personal characteristics and socioeconomic support for becoming an athlete.

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Section: Gpmur Blood Type As a Potential Inborn Physical Advantagementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

What Decides Your Athletic Career?—Reflection from Our Study of GP.Mur-Associated Sports Talents during the COVID-19 Pandemic Era

Hsu

Tseng

2022

IJERPH

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“…We came across this perplexing topic of research when we were conducting human exercise tests that examined the impacts of GP.Mur on respiration and unexpectedly found a significant association between GP.Mur and higher blood pressure. GP.Mur (a glycophorin B-A-B variant exclusively expressed on human RBCs) is a blood type unique to Southeast Asian (SEA) populations, with ∼4.7% prevalence in Taiwan and 2–23% in many areas of SEA, and is rare among non-SEA ethnic populations (e.g., Japanese and other ethnic groups of the Northeastern Asian origins) ( Prathiba et al, 2002 ; Hsu et al, 2013 ; Wei et al, 2016 ; Jongruamklang et al, 2020 ; Yang et al, 2021 ; Kaito et al, 2022 ). The main molecular function of GP.Mur is to enhance AE1 protein expression on the RBC membrane ( Hsu et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Erythroid anion transport, nitric oxide, and blood pressure

Hsu

2024

Front. Physiol.

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Glycophorin A and glycophorin B are structural membrane glycoproteins bound in the band 3 multiprotein complexes on human red blood cells (RBCs). Band 3 is an erythroid-specific anion exchanger (AE1). AE1-mediated HCO3− transport provides the substrate for the enzyme-catalyzed conversion HCO3−(aq) ⇌ CO2(g), which takes place inside the RBCs. Bicarbonate transport via AE1 supports intravascular acid–base homeostasis and respiratory excretion of CO2. In the past decade, we conducted several comparative physiology studies on Taiwanese people having the glycophorin variant GPMur RBC type (which accompanies greater AE1 expression). We found that increased anion transport across the erythrocyte membrane not only enhances gas exchange and lung functions but also elevates blood pressure (BP) and reduces nitric oxide (NO)-dependent vasodilation and exhaled NO fraction (FeNO) in healthy individuals with GP.Mur. Notably, in people carrying the GPMur blood type, the BP and NO-dependent, flow-mediated vasodilation (FMD) are both more strongly correlated with individual hemoglobin (Hb) levels. As blood NO and nitrite (NO2−) are predominantly scavenged by intraerythrocytic Hb, and NO2− primarily enters RBCs via AE1, could a more monoanion-permeable RBC membrane (i.e., GPMur/increased AE1) enhance NO2−/NO3− permeability and Hb scavenging of NO2− and NO to affect blood pressure? In this perspective, a working model is proposed for the potential role of AE1 in intravascular NO availability, blood pressure, and clinical relevance.

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“…GP.Mur is a special red cell type with 1–10% prevalence in Southeast Asia [ 1 , 2 ]. GP stands for glycoprotein.…”

Section: Introductionmentioning

confidence: 99%

Different Involvement of Band 3 in Red Cell Deformability and Osmotic Fragility—A Comparative GP.Mur Erythrocyte Study

Kuo

Chuang

Cheng

et al. 2021

Cells

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GP.Mur is a clinically important red blood cell (RBC) phenotype in Southeast Asia. The molecular entity of GP.Mur is glycophorin B-A-B hybrid protein that promotes band 3 expression and band 3–AQP1 interaction, and alters the organization of band 3 complexes with Rh/RhAG complexes. GP.Mur+ RBCs are more resistant to osmotic stress. To explore whether GP.Mur+ RBCs could be structurally more resilient, we compared deformability and osmotic fragility of fresh RBCs from 145 adults without major illness (47% GP.Mur). We also evaluated potential impacts of cellular and lipid factors on RBC deformability and osmotic resistivity. Contrary to our anticipation, these two physical properties were independent from each other based on multivariate regression analyses. GP.Mur+ RBCs were less deformable than non-GP.Mur RBCs. We also unexpectedly found 25% microcytosis in GP.Mur+ female subjects (10/40). Both microcytosis and membrane cholesterol reduced deformability, but the latter was only observed in non-GP.Mur and not GP.Mur+ normocytes. The osmotic fragility of erythrocytes was not affected by microcytosis; instead, larger mean corpuscular volume (MCV) increased the chances of hypotonic burst. From comparison with GP.Mur+ RBCs, higher band 3 expression strengthened the structure of RBC membrane and submembranous cytoskeletal networks and thereby reduced cell deformability; stronger band 3–AQP1 interaction additionally supported osmotic resistance. Thus, red cell deformability and osmotic resistivity involve distinct structural–functional roles of band 3.

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Universal Detection of Mia Antigen and Frequencies of Glycophorin Hybrids among Blood Donors in Taiwan by Human Monoclonal Antibodies against Mia (MNS7), Mur (MNS10), and MUT (MNS35) Antigens

Cited by 6 publications

References 33 publications

What Decides Your Athletic Career?—Reflection from Our Study of GP.Mur-Associated Sports Talents during the COVID-19 Pandemic Era

What Decides Your Athletic Career?—Reflection from Our Study of GP.Mur-Associated Sports Talents during the COVID-19 Pandemic Era

Erythroid anion transport, nitric oxide, and blood pressure

Different Involvement of Band 3 in Red Cell Deformability and Osmotic Fragility—A Comparative GP.Mur Erythrocyte Study

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