Universal Head Ultrasound Screening in Full-term Neonates: A Retrospective Analysis of 6771 Infants

Ballardini, Elisa; Tarocco, Anna; Rosignoli, Chiara; Baldan, Alessandro; Borgna‐Pignatti, Caterina; Garani, Giampaolo

doi:10.1016/j.pediatrneurol.2017.03.012

Cited by 12 publications

(15 citation statements)

References 14 publications

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“…Similar to the results of Hsu et al and Ballardini et al, the most common minor findings were subependymal cysts, followed by choroid plexus cysts. 6,7 The incidence rate of subependymal cysts in our study was higher than that of previous study (8.99% vs 5%). 10 The proportion of neonates who had choroid plexus cysts in this study was lower than that in the study of Hung and Liao (2.43% vs 8.8%).…”

Section: Discussioncontrasting

confidence: 67%

“…6 Ballardini et al showed that in 6771 full-term neonates, the incidence rates of abnormal findings and major abnormalities were 1.7% and 0.19%, respectively. 7 The incidence rates of any ultrasound abnormalities can be as high as 20%. 3 In our study, 17.3% of healthy neonates had abnormal CUS findings, of whom 0.28% presented with major anomalies.…”

Section: Discussionmentioning

confidence: 99%

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Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes

Lin

Chiu

Chen

et al. 2021

Pediatrics & Neonatology

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Background: To analyze the findings of cranial ultrasonographic screening in asymptomatic neonates and to assess the association between abnormal results and neurodevelopment. Methods: We retrospectively reviewed the cranial ultrasonographic screening results of healthy neonates born between 35 and 42 weeks gestation at our hospital from October 2011 to October 2018. Results: In total, 11,681 neonates underwent cranial ultrasonographic screening during the study period, and 9666 (82.7%) had normal results. Of 2015 neonates with abnormal findings, 294 had more than two abnormalities. The most common minor findings were subependymal cysts (8.99%), choroid plexus cysts (2.43%), lenticulostriate vasculopathy (2.34%), frontal horn cysts (1.80%), and enlarged cisterna magna (1.04%). Then, 33 (0.28%) neonates had major abnormalities, including cerebral hemorrhage, periventricular heterotopia, focal cortical dysplasia, anomalies of the corpus callosum, and vascular malformation. Of 1334 neonates who underwent serial clinical evaluations, 76 (5.69%) had neurodevelopmental disorders, including developmental delay, attention-deficit/hyperactivity disorder, and autistic spectrum disorder. Conclusion: The incidence rate of intracranial anomalies in healthy neonates was 17.3%, and about 5.69% had neurodevelopmental disorders. Cranial ultrasonographic screening has its own value in helping early detection of intracranial anomalies in healthy neonates, some of which have prognostic implications.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes

Lin

Chiu

Chen

et al. 2021

Pediatrics & Neonatology

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“…Among the 117 neonates without an indication for CU, but with CU conspicuities, 85.5% had MCs and 14.5% had SCs. Ballardini et al postulated a prevalence of 1.7% for conspicuous CUs in asymptomatic neonates aged > 37 weeks GA, and the distribution of MCs and SCs was similar to that in the present study [10]. The prevalence of SCs was 0.33% in group II, which was higher than the prevalence of significant anomalies found by Ballardini et al (0.19%) or that found by Wang et al (0.25%) [10, 11].…”

Section: Discussionsupporting

confidence: 91%

Analyses of pathological cranial ultrasound findings in neonates that fall outside recent indication guidelines: results of a population-based birth cohort: survey of neonates in Pommerania (SNiP-study)

et al. 2019

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BackgroundRecent guidelines recommend a cranial ultrasound (CU) in neonates born at < 30 weeks gestation, admitted to the neonatal intensive care unit (NICU), or with a CU indication. Here, we addressed the need to extend these recommendations.MethodsWe retrospectively reviewed 5107 CUs acquired in the population-based Survey of Neonates in Pomerania, conducted in 2002 to 2008. Neonates with conspicuous CUs that were ≥ 30 weeks gestation without recent indications for CU were identified and assigned to the following groups: with (I) or without (II) admission to neonatal care. We designated CU conspicuities as mild (MC) or significant (SC), and we investigated related neurodevelopment during follow-up.ResultsOf 5107 neonates, 5064 were born at ≥30 weeks gestation and of those, 4306 received CUs without any indication for this examination. We found conspicuities in 7.7% (n = 47/610) of group I (n = 30 MC, n = 17 SC), and 3.2% (n = 117/3696) of group II (n = 100 MC, n = 17 SC). In group II, SC comprised, e.g., bilateral cysts, partial agenesis of the corpus callosum, and periventricular leukomalacia. Follow-up was available in 75% of infants in group II with MCs and SCs; of these, 12.8% had an abnormal neurological follow-up.ConclusionsWe detected a high number of conspicuities in neonates without a CU indication. However, we could not demonstrate that ultrasound findings were associated with the neurological follow-up or any advantage to an earlier diagnosis. Our data did not support extending current guidelines or a general CU screening policy for all neonates.

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“…While in our prospective cohort study a substantial number of non-specific, non-contributory incidental findings were seen on routine CUSS (n = 34, 17.0 %), no relevant intracerebral or cranial pathology or skull fracture was detected using cerebral ultrasonography imaging. In comparison to the study by Ballardini et al [27] including 6771 healthy term neonates, the rate of incidental findings in our cohort was substantially higher. It is of note that only 114 of 6771 (1.7 %) presented ultrasound abnormalities in their study, while 6657 were normal or exhibited insignificant findings.…”

Section: Discussioncontrasting

confidence: 90%

“…In 101 of 114 (88.6 %) abnormalities were minor, and only 13 infants had major abnormalities (0.19 % of all full-term newborns). Importantly, all neonates with major abnormalities presented with either microcephaly or abnormal neurological evaluations, and only one individual with major abnormalities was detected exclusively by ultrasound [27].…”

Section: Discussionmentioning

confidence: 99%

Is There a Role for Cerebral Ultrasonography in Near-Term/Term Neonates Following Assisted Vaginal Delivery? A Prospective, Single-Center Study

et al. 2020

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Aim To evaluate the role of cerebral ultrasonography studies (CUSS) in detecting intracerebral and cranial pathologies (hemorrhages, ischemia, skull fractures) in near-term and term neonates following assisted vaginal delivery. Patients and Methods Prospective single-center study (11/2017–11/2018) at the University Children’s Hospital of Saarland, Homburg, Germany including newborns with a gestational age ≥ 36 weeks born by assisted vaginal delivery. In all newborns, a standardized CUSS was performed within the first three days of life prior to discharge. Results 200 neonates (43.0 % female, 57.0 % male; gestational age 39.6 ± 1.3 weeks) were included in this study (birth weight 3345.6 ± 450.6 g, body length 51.7 ± 2.5 cm, head circumference 35.0 ± 1.5 cm). 67 (33.5 %) neonates had minor external injuries of the scalp. 5 children showed clinical neurologic abnormalities: 4 (2.0 %) seizures and 1 facial palsy (0.5 %). In 34 (17.0 %) patients, minor incidental intracranial abnormalities unrelated to mode of delivery were detected on CUSS. No intracerebral, cranial pathologies or skull fractures were seen on routine CUSS. Conclusion Routine CUSS in newborns after assisted vaginal delivery did not yield clinically relevant results in our cohort. Clinical observation and selective CUSS in symptomatic newborns might be more efficient than routine CUSS.

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Universal Head Ultrasound Screening in Full-term Neonates: A Retrospective Analysis of 6771 Infants

Cited by 12 publications

References 14 publications

Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes

Cranial ultrasonographic screening findings among healthy neonates and their association with neurodevelopmental outcomes

Analyses of pathological cranial ultrasound findings in neonates that fall outside recent indication guidelines: results of a population-based birth cohort: survey of neonates in Pommerania (SNiP-study)

Is There a Role for Cerebral Ultrasonography in Near-Term/Term Neonates Following Assisted Vaginal Delivery? A Prospective, Single-Center Study

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