Universal Screening for SARS-CoV-2 in Women Admitted for Delivery

Sutton, Desmond; Fuchs, Karin; D’Alton, Mary E.; Goffman, Dena

doi:10.1056/nejmc2009316

Cited by 1,012 publications

(1,082 citation statements)

References 3 publications

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“…Recently published case series discuss clinical features and outcomes of pregnant women with suspected COVID-19. [1][2][3][4] In 1 series of 13 mothers with confirmed SARS-CoV-2 infection postpartum, 2 had a dry cough and 6 had ground-glass opacity infiltrates on chest CT. 1 In another retrospective single-centre study, 7 pregnant (third-trimester) women who tested positive for SARS-CoV-2 infection had infiltrates on CT consistent with infection but did not require intensive care postpartum. 2 Of a total of 20 reported patients, none developed postpartum acute decompensation.…”

Section: Discussionmentioning

confidence: 99%

Postpartum exacerbation of antenatal COVID-19 pneumonia in 3 women

Wood

et al. 2020

CMAJ

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A 31-year-old pregnant woman (38 wk + 2 d) presented to the obstetrics and gynecology team with a 5-day history of cough, low-grade fever (maximum temperature 37.8°C) and intermittent shortness of breath. She also described bilateral lower-leg edema for 2 days. Because she reported contact with a potentially infected person from Wuhan, China, the epicentre of the coronavirus disease 2019 (COVID-19) outbreak, we placed her immediately in respiratory isolation.The patient's oxygen saturations were 90%-94%, respiratory rate was 28 breaths/min, heart rate was 90 beats/min and blood pressure was 160/100 mm Hg at the time of admission. Results of initial laboratory tests were as follows: leukocyte count 5.1 (reference range 3.5-9.5) ×10 9 /L, lymphocyte count 1.05 (reference range 1.1-3.2) ×10 9 /L and C-reactive protein (CRP) level 7.1 (reference range 0-8) mg/L. Real-time polymerase chain reaction (PCR) testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was positive. Fetal ultrasonography and maternal echocardiography were normal.We performed low-dose computed tomography (CT) of the chest to exclude pulmonary embolism and pneumonia; CT results were normal ( Figure 1A). After a failed induction of labour, the patient underwent a cesarean delivery, delivering a healthy boy weighing 4.2 kg. The newborn tested negative for SARS-CoV-2 by real-time PCR throat and anal swabs. After delivery, we prescribed the patient an antiviral treatment typically used for influenza, umifenovir. PRACTICE | CASES CPD

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Section: Discussionmentioning

confidence: 99%

Postpartum exacerbation of antenatal COVID-19 pneumonia in 3 women

Wood

et al. 2020

CMAJ

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“…Our goal is to minimize its variance by strategically allocating finite samples in order to minimize the important posterior variances among the elements of θ. In plain language, some of the subpopulations are more important in shaping future disease dynamics than others, so MDI will preferentially allocate more samples to those subpopulations in a principled manner, 1 The next generation matrix N is non-negative and satisfies the conditions of the Perron-Frobenius theorem which means that it has a largest eigenvalue λ-for a next generation matrix, R 0 = λ-which is greater than or equal to all other eigenvalues, with a corresponding eigenvector x of non-negative components. This means that repeated applications of N to any initial vector that is not orthogonal to x will become increasingly parallel to x at a rate of λ/|λ 2 | per iteration, where λ 2 is the second largest eigenvalue of N .…”

Section: S22 Minimizing Posterior Uncertainty For Modelingmentioning

confidence: 99%

“…(S11) and modification as in Eq. (S12), the next generation matrix updates the vector of infected individuals per subpopulation ash t+1 = (I − D θ )N h t ≈ (I − D θ )kλx (S8)where x represents the eigenvector of N corresponding to the largest eigenvalue λ, and k is a constant k = x T h 1. There are two helpful interpretations of this equation.…”

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confidence: 99%

Estimating SARS-CoV-2 seroprevalence and epidemiological parameters with uncertainty from serological surveys

Larremore

Fosdick

Bubar

et al. 2020

Preprint

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and ygrad@hsph.harvard.edu.Establishing how many people have already been infected by SARS-CoV-2 is an urgent priority for controlling the COVID-19 pandemic. Patchy virological testing has hampered interpretation of confirmed case counts, and unknown rates of asymptomatic and mild infections make it challenging to de-1 . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review)

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“…Recent evidence suggests asymptomatic prevalence may be as high as 15% in specific populations, potentially affecting strategies for screening and tracing in some regions. [5] Antibody testing is still not widely available, making it difficult to honestly assess the breadth of the pandemic and the potential for herd immunity. Vaccinations will also be a vital aspect of any future population-level interventions, although the timeline of their availability remains unclear.…”

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confidence: 99%