2018
DOI: 10.1007/s11538-018-00558-w
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Universal Statistics of Incubation Periods and Other Detection Times via Diffusion Models

Abstract: We suggest an explanation of typical incubation times statistical features based on the universal behavior of exit times for diffusion models. We give a mathematically rigorous proof of the characteristic right skewness of the incubation time distribution for very general onedimensional diffusion models. Imposing natural simple conditions on the drift coefficient, we also study these diffusion models under the assumption of noise smallness and show that the limiting exit time distributions in the limit of vani… Show more

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Cited by 4 publications
(2 citation statements)
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“…This approach allows us to characterize the asymptotic shape of the fixation-time distribution in terms of the constants κ n . Since λ m > 0, it is clear from this expression that, for finite N , the skew and all higher order cumulants must be positive, in agreement with results for random walks with non-uniform bias [34]. As N → ∞ this is not necessarily true; in some cases the cumulants vanish.…”
Section: A Eigendecomposition Of the Birth-death Processsupporting
confidence: 82%
“…This approach allows us to characterize the asymptotic shape of the fixation-time distribution in terms of the constants κ n . Since λ m > 0, it is clear from this expression that, for finite N , the skew and all higher order cumulants must be positive, in agreement with results for random walks with non-uniform bias [34]. As N → ∞ this is not necessarily true; in some cases the cumulants vanish.…”
Section: A Eigendecomposition Of the Birth-death Processsupporting
confidence: 82%
“…An advantage of using the median exit time is that it is less dependent on the tail of the distribution of exit times. This is important because exit time distribution tends to be right-skewed (31-33)-a universal feature that can be understood from simple diffusion models (34). The consequences become extreme if the distribution of exit times has a fat tail, and no mean value can be computed at all.…”
Section: The Approach In a Nutshellmentioning
confidence: 99%