Original scientific paper https://doi.org/10.2298/TSCI191016004SIn order to study a new clean and efficient combustion mode, which can relieve the pressure of traditional energy and ensure low emissions, in this study, a diesel/natural gas dual fuel engine is designed by non-dominant sorting genetic algorithm (NSGA-Ⅱ), and its thermodynamic characteristics are studied. The WP10.290 Diesel engine is modified into a diesel/natural gas dual fuel engine. The emissions of harmful substances and thermal efficiency of the modified engine under different working conditions are compared. The combustion chamber structure and adaptability between combustion chamber and injection parameters are optimized by using NSGA-II algorithm and CFD software. The results show that the emission of NO x and CH 4 and the fuel consumption rate can be reduced simultaneously by using the composite combustion model compared with the original engine. When the CH 4 emission is close to zero, the fuel consumption rate decreases obviously, and NO x slightly increases. When the angle between the injection holes is 141.57, the amount of NO x in the cylinder is large. When the injection advance angle is 21.91 CA, the pressure in the cylinder is the highest, the CH 4 production is the lowest, the NO x production is higher, and the oxygen content in the combustion mixture is less. The NO x production is the lowest. diesel/natural gas dual fuel engine can ensure efficient combustion while reducing emissions. In this study, the performance of the dual fuel engine at various speeds can be further studied, which can provide theoretical support for the design of diesel/natural gas dual fuel engine.