Interpersonal communication and self-adaptation are two factors that can influence the work readiness of students. This study aims to find out the effect of interpersonal communication and self-adaptation to students' work readiness. The subjects in this study were students of class XII of SMK Negeri 1 Seyegan totaling 174 students. The sampling technique is cluster random sampling. Methods of data collection in this study are work readiness scale, interpersonal communication scale, and self-adaptation scale. Meanwhile, data analysis is multiple linear regression analysis. The results of data analysis showed a very significant effect of interpersonal communication and self-adjustment simultaneously on work readiness, with an F value of 74.382 and a significance level (p) of .000 (p <.01). Having better interpersonal communication and adjustment of students, the better work readiness of students and the worse the interpersonal communication and adjustment of students, the lower work readiness of students.