Univerzitetne knjižnice v Bolgariji danes

Yankova, Ivanka

doi:10.3359/oz0604178

Cited by 1 publication

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“…It produces a bacteriostatic effect by the selective inhibition of the bacterial DNA synthesis. [5][6][7] Furthermore, some of these chromatographic methods 6,7 require high strength ionic buffered mobile phases which are hazardous for column efficiency and need prolonged time for column saturation and washing. Nitroxoline is active against susceptible Gram-positive and Gram-negative organisms in urinary tract infections.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric analysis of nitroxoline in tablets and human serum using modified carbon paste electrodes incorporating mesoporous carbon or multiwalled carbon nanotubes

et al. 2015

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Mesoporous carbon (MC) was synthesized using a mesoporous SiO 2 template material (SBA-15) and sucrose as the carbon source. SBA-15, MC as well as commercially obtained multi-walled carbon nanotubes (MWCNTs) were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), N 2 sorption isotherms and electrochemical impedance spectra. A carbon paste (CP) electrode modified with either MC or MWCNTs was used as a sensor for sensitive and selective determination of the nitroxoline drug. Using cyclic voltammetry, linear sweep and square-wave adsorptive stripping voltammetry, nitroxoline was found to oxidize via one developed peak at MWCNT/ CP and MC/CP electrodes compared to unmodified one. This is attributed to the stronger adsorptive character, lower charge transfer resistances and higher electrocatalytic activities of modified CP electrodes than the unmodified CP electrode. A well-defined peak and high current response were observed in a B-R universal buffer (pH 2.5) following preconcentration of nitroxoline by adsorption accumulation at À0.2 V (vs. Ag/AgCl/KCl s ). Limits of detection of 3.0 Â 10 À11 , 1.5 Â 10 À11 and 3.0 Â 10 À12 M nitroxoline, were obtained using the unmodified CP, MWCNT/CP and MC/CP electrodes, respectively. The utility of these sensors was examined for the determination of nitroxoline in its pharmaceutical dosage form (Nibiol® tablets) and human serum.

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Section: Introductionmentioning

confidence: 99%