Is technological advancement constrained by biases in human cognition? People in all societies build on discoveries inherited from previous generations, leading to cumulative innovation. However, biases in human learning and memory may influence the process of knowledge transmission, potentially limiting this process. Here we show that cumulative innovation in a continuous optimization problem is systematically constrained by human biases. In a large (n = 1,250) behavioral study using a transmission chain design, participants searched for virtual technologies in one of four environments after inheriting a solution from previous generations. Participants converged on worse solutions in environments misaligned with their biases. These results substantiate a mathematical model of cumulative innovation in Bayesian agents, highlighting formal relationships between cultural evolution and distributed stochastic optimization. Our findings provide experimental evidence that human biases can limit the advancement of knowledge in a controlled laboratory setting, reinforcing concerns about bias in creative, scientific, and educational contexts.