Unleashing the potential: integrating nano-delivery systems with traditional Chinese medicine

Zou, Jianhua; Li, Meng; Liu, Ziwei; Luo, Wei; Han, Shiqi; Xiao, Fan; Tao, Wei; Wu, Qibiao; Xie, Tian; Kong, Na

doi:10.1039/d3nr06102g

Cited by 4 publications

(1 citation statement)

References 128 publications

(154 reference statements)

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“…Currently, cinobufacini capsules and tablets in clinical use are administered orally, but this method is limited by poor water solubility, low permeability, instability, rapid metabolic elimination in the intestine and liver. 168 Cinobufacini and TV injections can overcome the limitations of oral administration via intramuscular or intravenous injection, but they exhibit rapid blood clearance, toxic side effects at high concentrations, and weak tumor targeting, resulting in suboptimal effects. Numerous studies have demonstrated that TS/TV and active ingredients of TDDS were designed by intravenous administration delivery, which allowed them to improve water solubility, enhance stability, prolong blood circulation time, reduce internal clearance, and have good tumor targeting, thereby enhancing their therapeutic efficacy.…”

Section: Conclusion and Prospectivesmentioning

confidence: 99%

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Zhang,

Zhai,

Sun

et al. 2024

IJN

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Dried toad skin (TS) and toad venom (TV) are the dried skin of the Bufo bufo gargarizans Cantor and the Bufo melanostictus Schneider , which remove the internal organs and the white secretions of the skin and retroauricular glands. Since 2005, cinobufacini preparations have been approved by the State Food and Drug Administration for use as adjuvant therapies in the treatment of various advanced cancers. Meanwhile, bufalenolides has been identified as the main component of TS/TV, exhibiting antitumor activity, inducing apoptosis of cancer cells and inhibiting cancer cell proliferation or metastasis through a variety of signaling pathways. However, clinical agents frequently face limitations such as inherent toxicity at high concentrations and insufficient tumor targeting. Additionally, the development and utilization of these active ingredients are hindered by poor water solubility, low bioavailability, and rapid clearance from the bloodstream. To address these challenges, the design of a targeted drug delivery system (TDDS) aims to enhance drug bioavailability, improve targeting within the body, increase drug efficacy, and reduce adverse reactions. This article reviews the TDDS for TS/TV, and their active components, including passive, active, and stimuli-responsive TDDS, to provide a reference for advancing their clinical development and use.

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Section: Conclusion and Prospectivesmentioning

confidence: 99%

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Zhang,

Zhai,

Sun

et al. 2024

IJN

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Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review

Pei,

Palanisamy,

Natarajan

et al. 2024

Ageing Research Reviews

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Exploiting the nanotechnological approaches for traditional Chinese medicine in childhood rhinitis: A review of future perspectives

Zhang,

Dong,

Zhu

et al. 2024

Nanotechnology Reviews

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Childhood rhinitis is an inflammatory condition affecting the nasal mucosa of children worldwide. The physical, social, and cognitive performance of children is affected by the chronic symptoms of childhood rhinitis. Effective treatment is essential to avoid long-term effects on children’s lifestyles and well-being. Traditional Chinese medicine (TCM) has been used to treat and prevent several illnesses, and it plays a crucial role in healthcare and rehabilitation. TCM has traditionally been used to holistically treat rhinitis. However, the drawbacks of TCMs, such as their poor water solubility, low bioavailability, single-use, and poor targeting ability, severely restrict their use. In recent years, nanotechnology has been used for various drugs to improve their therapeutic effectiveness and reduce their associated adverse effects. Nanomaterials for TCM formulations are synthesized to be compatible with herbal extracts and sustain active component therapeutic qualities. Nanocarrier-based drug delivery improves bioavailability, circulation time, and targeted distribution, resolving TCM administration issues. This review assesses the innovative combination of TCM and nanotechnology developments for the treatment of childhood rhinitis, providing insights into novel therapeutic approaches. This review also provides significant insights into the potential of this multidisciplinary approach to transform treatment techniques in childhood rhinitis and offers a road map for future research initiatives in this promising sector.

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Unleashing the potential: integrating nano-delivery systems with traditional Chinese medicine

Abstract: This review explores the potential of integrating nano-delivery systems with traditional Chinese herbal medicine, acupuncture, and Chinese medical theory. It highlights the intersections and potential of nano-delivery systems in enhancing...

Cited by 4 publications

References 128 publications

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review

Exploiting the nanotechnological approaches for traditional Chinese medicine in childhood rhinitis: A review of future perspectives

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