Unleashing the potential of QCM: A comprehensive review of aptamer-based QCM sensing analysis

Dong, Haowei; Huang, Jingcheng; Guo, Zhen; Jia, Peng; Sun, Zhicong; Guo, Yemin; Sun, Xia

doi:10.1016/j.microc.2024.110344

Cited by 4 publications

(3 citation statements)

References 113 publications

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“…QCM aptasensors proved their worth by reliably detecting Sars-Cov-2 [181,182], Brucella sp. in milk [183], avian influenza virus [184], and hepatitis B [185] and C [186] viruses, as well as the detection of toxins in the environment [187][188][189]. A number of studies have demonstrated the value of aptamers in QCM methodology, particularly in the field of clinical diagnostics.…”

Section: Quartz Crystal Microbalance (Qcm) Aptasensorsmentioning

confidence: 99%

New Insights into Aptamers: An Alternative to Antibodies in the Detection of Molecular Biomarkers

Domsicova,

Korcekova,

Poturnayova

et al. 2024

IJMS

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Aptamers are short oligonucleotides with single-stranded regions or peptides that recently started to transform the field of diagnostics. Their unique ability to bind to specific target molecules with high affinity and specificity is at least comparable to many traditional biorecognition elements. Aptamers are synthetically produced, with a compact size that facilitates deeper tissue penetration and improved cellular targeting. Furthermore, they can be easily modified with various labels or functional groups, tailoring them for diverse applications. Even more uniquely, aptamers can be regenerated after use, making aptasensors a cost-effective and sustainable alternative compared to disposable biosensors. This review delves into the inherent properties of aptamers that make them advantageous in established diagnostic methods. Furthermore, we will examine some of the limitations of aptamers, such as the need to engage in bioinformatics procedures in order to understand the relationship between the structure of the aptamer and its binding abilities. The objective is to develop a targeted design for specific targets. We analyse the process of aptamer selection and design by exploring the current landscape of aptamer utilisation across various industries. Here, we illuminate the potential advantages and applications of aptamers in a range of diagnostic techniques, with a specific focus on quartz crystal microbalance (QCM) aptasensors and their integration into the well-established ELISA method. This review serves as a comprehensive resource, summarising the latest knowledge and applications of aptamers, particularly highlighting their potential to revolutionise diagnostic approaches.

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Section: Quartz Crystal Microbalance (Qcm) Aptasensorsmentioning

confidence: 99%

New Insights into Aptamers: An Alternative to Antibodies in the Detection of Molecular Biomarkers

Domsicova,

Korcekova,

Poturnayova

et al. 2024

IJMS

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show abstract

“…In this context, it is evident how monitoring other quantities related to the resonant behavior of the quartz can be beneficial, as it provides additional information about the interaction with the target substance. This is usually attained by exploiting different measurement techniques, ranging from impedance analysis [6][7][8][9][10] to simpler and lower-cost ones such as those based on frequency measurement associated with dissipation monitoring [11][12][13][14][15][16], or on a variant of oscillator-based systems, called QCM-R, recently proposed to simultaneously obtain a measurement of the dissipative behavior of the quartz [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

“…This is usually attained by exploiting different measurement techniques, ranging from impedance analysis [ 6 , 7 , 8 , 9 , 10 ] to simpler and lower-cost ones such as those based on frequency measurement associated with dissipation monitoring [ 11 , 12 , 13 , 14 , 15 , 16 ], or on a variant of oscillator-based systems, called QCM-R, recently proposed to simultaneously obtain a measurement of the dissipative behavior of the quartz [ 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Front-End Electronics on Metrological Performance of QCM Systems

Fort,

Landi,

Moretti

et al. 2024

Sensors

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Quartz Crystal Microbalances (QCMs) are versatile sensors employed in various fields, from environmental monitoring to biomedical applications, owing mainly to their very high sensitivity. However, the assessment of their metrological performance, including the impact of conditioning circuits, digital processing algorithms, and working conditions, is a complex and novel area of study. The purpose of this work is to investigate and understand the measurement errors associated with different QCM measurement techniques, specifically focusing on the influence of conditioning electronic circuits. Through a tailored and novel experimental setup, two measurement architectures—a Quartz Crystal Microbalance with dissipation monitoring (QCM-D) system and an oscillator-based QCM-R system—were compared under the same mechanical load conditions. Through rigorous experimentation and signal processing techniques, the study elucidated the complexities of accurately assessing QCM parameters, especially in liquid environments and under large mechanical loads. The comparison between the two different techniques allows for highlighting the critical aspects of the measurement techniques. The experimental results were discussed and interpreted based on models allowing for a deep understanding of the measurement problems encountered with QCM-based measurement systems. The performance of the different techniques was derived, showing that while the QCM-D technique exhibited higher accuracy, the QCM-R technique offered greater precision with a simpler design. This research advances our understanding of QCM-based measurements, providing insights for designing robust measurement systems adaptable to diverse conditions, thus enhancing their effectiveness in various applications.

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Elimination of the interference from non-specific adsorption on molecularly imprinted sensors in capacitive and piezoelectric microgravimetry dual-mode via a differential strategy demonstrated by 2,4-dichlorophenoxyacetic acid determination

Ge,

Dou,

et al. 2024

Journal of Electroanalytical Chemistry

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Unleashing the potential of QCM: A comprehensive review of aptamer-based QCM sensing analysis

Cited by 4 publications

References 113 publications

New Insights into Aptamers: An Alternative to Antibodies in the Detection of Molecular Biomarkers

New Insights into Aptamers: An Alternative to Antibodies in the Detection of Molecular Biomarkers

Influence of Front-End Electronics on Metrological Performance of QCM Systems

Elimination of the interference from non-specific adsorption on molecularly imprinted sensors in capacitive and piezoelectric microgravimetry dual-mode via a differential strategy demonstrated by 2,4-dichlorophenoxyacetic acid determination

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