Unlike reactivity of mono- and binuclear imine-copper(II) complexes toward melanoma cells via a tyrosinase-dependent mechanism

Nunes, Cléia Justino; Otake, Andréia Hanada; Bustos, Silvina Odete; Fazzi, Rodrigo Boni; Chammas, Roger; Ferreira, Ana Maria da Costa

doi:10.1016/j.cbi.2019.108789

Cited by 8 publications

(10 citation statements)

References 40 publications

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“…Copper, a biologically active metal ion, possesses distinctive hydrolytic and redox properties. The Cu 2+ is able to form complexes with various coordination numbers and geometries, offering promising therapeutic applications [104,105]. As an example, the cytotoxic binuclear Cu 2+ complex [Cu(phen) 2 ] + (phen = 1,10-phenanthroline) has been reported to bind DNA and to induce single-stranded breaks [106].…”

Section: Advancing Melanoma Systemic Treatment—potential Targets Amentioning

confidence: 99%

Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma

2019

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Melanoma is an aggressive form of skin cancer, being one of the deadliest cancers in the world. The current treatment options involve surgery, radiotherapy, targeted therapy, immunotherapy and the use of chemotherapeutic agents. Although the last approach is the most used, the high toxicity and the lack of efficacy in advanced stages of the disease have demanded the search for novel bioactive molecules and/or efficient drug delivery systems. The current review aims to discuss the most recent advances on the elucidation of potential targets for melanoma treatment, such as aquaporin-3 and tyrosinase. In addition, the role of nanotechnology as a valuable strategy to effectively deliver selective drugs is emphasized, either incorporating/encapsulating synthetic molecules or natural-derived compounds in lipid-based nanosystems such as liposomes. Nanoformulated compounds have been explored for their improved anticancer activity against melanoma and promising results have been obtained. Indeed, they displayed improved physicochemical properties and higher accumulation in tumoral tissues, which potentiated the efficacy of the compounds in pre-clinical experiments. Overall, these experiments opened new doors for the discovery and development of more effective drug formulations for melanoma treatment.

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Section: Advancing Melanoma Systemic Treatment—potential Targets Amentioning

confidence: 99%

Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma

2019

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“…Furthermore, no effects on autophagy were observed in vivo and in vitro B16 models using the organic compound O,O -diethyl-(S,S)-ethylenediamine- N,N ′di-2-(3-cyclohexyl) propanoate dihydrochloride, which caused apoptosis, disruption of mitochondrial membrane potential and oxidative stress, leading to decreased tumour growth [ 108 ]. Results on the toxicity of copper complexes mononuclear complex 1 and dinuclear complex 2 have shown that susceptibility to these compounds in SK-Mel 05 and SK-Mel 147 cells is related to melanin content and is favoured by UV-B irradiation, which induces melanogenesis, ROS formation, and apoptosis, likely involving autophagic death process [ 109 ]. Conversely, apoptosis induction and autophagic flux blockade was detected after the administration of photoactive NADPH analogue NS1 [ 110 ].…”

Section: Melanoma Cell Death and Survival: Simultaneous Regulation Of Oxidative Stress System And Autophagy Machinerymentioning

confidence: 99%

Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate

Catalani

Giovarelli

Zecchini

et al. 2021

Cancers

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Melanoma originates from the malignant transformation of melanocytes and is one of the most aggressive forms of cancer. The recent approval of several drugs has increased the chance of survival although a significant subset of patients with metastatic melanoma do not show a long-lasting response to these treatments. The complex cross-talk between oxidative stress and the catabolic process autophagy seems to play a central role in all aspects of melanoma pathophysiology, from initiation to progression and metastasis, including drug resistance. However, determining the fine role of autophagy in cancer death and in response to redox disruption is still a fundamental challenge in order to advance both basic and translational aspects of this field. In order to summarize the interactions among reactive oxygen and nitrogen species, autophagy machinery and proliferation/growth/death/apoptosis/survival, we provide here a narrative review of the preclinical evidence for drugs/treatments that modulate oxidative stress and autophagy in melanoma cells. The significance and the potential for pharmacological targeting (also through multiple and combination approaches) of these two different events, which can contribute independently or simultaneously to the fate of melanoma, may help to define new processes and their interconnections underlying skin cancer biology and unravel new reliable approaches.

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“…13,14 Meanwhile, copper produces a variable valence ROS (Reactive Oxygen Species) during the transformation from Cu(II) to Cu(I) as a fundamental trace factor for the human body, which can cause tumor cells apoptosis and death. [15][16][17][18] Hence, copper complexes are considered as substitute to cisplatin as antitumor drugs. [19][20][21] Aromatic carboxylic acids are widely used in the construction of complexes due to their excellent structural rigidity and thermal stability.…”

Section: Introductionmentioning

confidence: 99%

“… 13,14 Meanwhile, copper produces a variable valence ROS (Reactive Oxygen Species) during the transformation from Cu( ii ) to Cu( i ) as a fundamental trace factor for the human body, which can cause tumor cells apoptosis and death. 15–18 Hence, copper complexes are considered as substitute to cisplatin as antitumor drugs. 19–21…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structures, DNA interactions, and antitumor activity of two new dinuclear copper(ii) complexes with thiazole ligand

Zeng

Cai

et al. 2021

RSC Adv.

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Unlike reactivity of mono- and binuclear imine-copper(II) complexes toward melanoma cells via a tyrosinase-dependent mechanism

Cited by 8 publications

References 40 publications

Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma

Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma

Oxidative Stress and Autophagy as Key Targets in Melanoma Cell Fate

Synthesis, crystal structures, DNA interactions, and antitumor activity of two new dinuclear copper(ii) complexes with thiazole ligand

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