Unlocking Intracellular Protein Delivery by Harnessing Polymersomes Synthesized at Microliter Volumes using Photo‐PISA
Chalaisorn Thanapongpibul,
Omar Rifaie‐Graham,
Miina Ojansivu
et al.
Abstract:Efficient delivery of therapeutic proteins and vaccine antigens to intracellular targets is challenging due to generally poor cell membrane permeation and endolysosomal entrapment causing degradation. Herein, these challenges are addressed by developing an oxygen‐tolerant photoinitiated polymerization‐induced self‐assembly (Photo‐PISA) process, allowing for the microliter‐scale (10 µL) synthesis of protein‐loaded polymersomes directly in 1536‐well plates. High‐resolution techniques capable of analysis at a sin… Show more
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