2024
DOI: 10.1002/adtp.202400231
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Unlocking the Potential of Chemically Modified Nucleic Acid Therapeutics

Jingjing Gao,
Bhingaradiya Nutan,
Dorra Gargouri
et al.

Abstract: Nucleic acid therapeutics have demonstrated tremendous potential for treating diseases by targeting the genetic underpinnings at the transcriptomic level. However, their efficacy hinges on robust strategies to protect nucleic acids from degradation during circulation and to facilitate precise delivery to diseased tissues and cells. Here the critical roles of chemical modification and bioconjugation in advancing nucleic acid therapeutics for improved binding affinity, enhanced stability, and targeted delivery a… Show more

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