Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review

Abstract

BackgroundIn a world where hair loss, acne, and skin whitening are common concerns, ethosomes emerge as a captivating breakthrough in cosmetic drug delivery.MethodThis review provides a comprehensive overview of the ethosomal system and assesses its potential as an effective nanocarrier for delivering active ingredients to the skin. The focus is on exploring their applications in various pathologies, particularly skin disorders such as acne, hair loss, and skin pigmentation.ResultsEthosomes are a novel type of vesicular nanocarrier composed of high concentrations of ethanol (20‐45%) and phospholipids. Their unique structure and composition make them an ideal choice for transporting active ingredients through the skin, offering targeted and effective treatment. The inclusion of ethanol in ethosomes' composition gives them distinctive properties, including flexibility, deformability, and stability, facilitating deep penetration into the skin and enhancing medication deposition. Moreover, ethosomes improved theoverall drug‐loading capacity, and specificity of target treatmentConclusionEthosomes represent a unique and suitable approach for delivering active cosmetic ingredients in the treatment of hair loss, acne, and skin whitening, presenting a versatile alternative to traditional dermal delivery systems. Despite the challenges associated with their complex preparation and sensitivity to temperature and humidity, the remarkable potential benefits of ethosomes cannot be ignored. Further research is crucial to unlock their full potential, understand their limitations, and refine their formulations and administration methods. Ethosomes hold the promise of transforming the way we address these cosmetic concerns, offering an exciting glimpse into the future of advanced skincare solutions.

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“…Additionally, their ability to penetrate the skin is especially advantageous in cosmetic applications. 120,121 PEGylated liposomes, whose co-occurrences show a more even distribution across delivery routes, were an exception, without a marked preference for any one administration route. While most suitable for the intravenous route, PEGylated liposomes have been administered via other routes such as oral 122 and transdermal 123,124 as well.…”

“…Ethosomes consist of alcohol (ethanol) in addition to lipids to specifically improve penetration across skin , and have been explored in the delivery of antidiabetic and anti-inflammatory drug molecules. Additionally, their ability to penetrate the skin is especially advantageous in cosmetic applications. , PEGylated liposomes, whose co-occurrences show a more even distribution across delivery routes, were an exception, without a marked preference for any one administration route. While most suitable for the intravenous route, PEGylated liposomes have been administered via other routes such as oral and transdermal , as well.…”