Unlocking the potential of ultra-high dose fractionated radiation for effective treatment of glioblastoma
Xiao-Yan Lan,
Lukasz Kalkowski,
Cheng-Yan Chu
et al.
Abstract:Background: Conventional radiation therapy for glioblastoma (GBM) has limited efficacy. Regenerative medicine brings hope for repairing damaged tissue, opening opportunities for elevating the maximum acceptable radiation dose. In this study, we explored the effect of ultra-high dose fractionated radiation on brain injury and tumor responses in immunocompetent mice. We also evaluated the role of the HIF-1α under radiation.
Methods: Naïve and hypoxia-inducible factor-1 alpha (HIF-1α)+/- heterozygous mice receive… Show more
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